Overview

Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar- macological concentrations for the suppression of clinical manifesta- tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im- portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu- taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef- fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos- metic (e.g. telangiectasias, hypertrichosis) to seriously disabling (e.g. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (e.g. gastric haemorrhage). These adverse effects of GCs se- riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects.

Full Product Details

Author:   A. Cato ,  H. Schaecke ,  K. Asadullah
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2002
Volume:   40
Dimensions:   Width: 14.80cm , Height: 2.10cm , Length: 21.00cm
Weight:   0.531kg
ISBN:  

9783662046623

ISBN 10:   3662046628
Pages:   380
Publication Date:   03 October 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Glucocorticoids and Asthma.- 2 Immune Monitoring of Glucocorticoid Therapy.- 3 Topical Glucocorticoid Therapy in Dermatology.- 4 Bone Effects of Glucocorticoid Therapy.- 5 Corticosteroids in Ophthalmology.- 6 Special Problems in Glucocorticoid Treatment in Children.- 7 Functional Implications of Glucocorticoid Receptor Trafficking.- 8 The Dynamics of Intranuclear Movement and Chromatin Remodeling by the Glucocorticoid Receptor.- 9 Glucocorticoid Receptor Antagonism of AP-1 Activity by Inhibition of MAPK Family.- 10 Mast Cells as Targets for Glucocorticoids in the Treatment of Allergic Disorders.- 11 Cytosolic Glucocorticoid Receptor-Interacting Proteins.- 12 The Glucocorticoid Receptor ?-Isoform: A Perspective on Its Relevance in Human Health and Disease.- 13 Cooperation of Nuclear Transcription Factors Regulated by Steroid and Peptide Hormones.- 14 Induction and Repression of NF-?B-Driven Inflammatory Genes.- 15 DNA-Dependent Cofactor Selectivity of the Glucocorticoid Receptor.- 16 The Anti-inflammatory Action of Glucocorticoid Hormones.- 17 Analysis of Glucocorticoid Receptor Function in the Mouse by Gene Targeting.- 18 Glucocorticoid-Inducible Genes That Regulate T-Cell Function.- 19 Structural Analysis of the GR Ligand-Binding Domain.- 20 SEGRAs: A Novel Class of Anti-inflammatory Compounds.- Previous Volumes Published in This Series.

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