Overview

The Nobel laureate Otto Warburg-a cousin of the famous finance Warburgs-was widely regarded in his day as one of the most important biochemists of the twentieth century, a man whose research was integral to humanity's understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it. In Ravenous, Sam Apple reclaims Otto Warburg as a forgotten, morally compromised genius who pursued cancer single-mindedly even as Europe disintegrated around him. While the vast majority of Jewish scientists fled Germany in the anxious years leading up to World War II, Warburg remained in Berlin, working under the watchful eye of the dictatorship. With the Nazis goose-stepping their way across Europe, systematically rounding up and murdering millions of Jews, Warburg awoke each morning in an elegant, antiques-filled home and rode horses with his partner, Jacob Heiss, before delving into his research at the Kaiser Wilhelm Society. Hitler and other Nazi leaders, Apple shows, were deeply troubled by skyrocketing cancer rates across the Western world, viewing cancer as an existential threat akin to Judaism or homosexuality. Ironically, they viewed Warburg as Germany's best chance of survival. Setting Warburg's work against an absorbing history of cancer science, Apple follows him as he arrives at his central belief that cancer is a problem of metabolism. Though Warburg's metabolic approach to cancer was considered groundbreaking, his work was soon eclipsed in the early postwar era, after the discovery of the structure of DNA set off a search for the genetic origins of cancer. Remarkably, Warburg's theory has undergone a resurgence in our own time, as scientists have begun to investigate the dangers of sugar and the link between obesity and cancer, finding that the way we eat can influence how cancer cells take up nutrients and grow. Rooting his revelations in extensive archival research as well as dozens of interviews with today's leading cancer authorities, Apple demonstrates how Warburg's midcentury work may well hold the secret to why cancer became so common in the modern world and how we can reverse the trend. A tale of scientific discovery, personal peril, and the race to end a disastrous disease, Ravenous would be the stuff of the most inventive fiction were it not, in fact, true.

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9781324092018

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While millions of other Europeans with Jewish heritage were being rounded up and sent to their deaths, Otto Warburg enjoyed Nazi protection and a comfortable life in Berlin. Sam Apple, author of a new book, Ravenous, explores his remarkable tale of survival. -- BBC History Revealed The research that Warburg is best known for today, and the work that forms the backbone of Ravenous, is his discovery that cancer cells behave differently from healthy cells in two very specific ways: They consume massive amounts of glucose - Apple compares them to ravenous shipwrecked sailors - and they eschew aerobic respiration in favor of fermentation... Apple covers everything from Hitler's obsessive preoccupation with cancer to how the German Empire's transformation into an industrial powerhouse led to a Romanticism-fueled movement that emphasized both environmental and racial purity. The fact that Apple can make these stories... feel so immediate is a testament to his canny knack for choosing apposite details. -- Seth Mnookin - The New York Times Ravenous tells the story of an extraordinary life, and of the visionary work that sustained it... Apple has a gift for elegant analogies and illuminating similes... [An] exceptionally interesting and well-written book... -- Thomas Morris - Times Literary Supplement Eye-opening... filled with... outrageous and entertaining stories... I walked away from Ravenous thinking of Otto Warburg as a sort of Sigmund Freud of cancer research. -- Sam Kean - The Wall Street Journal

"""While millions of other Europeans with Jewish heritage were being rounded up and sent to their deaths, Otto Warburg enjoyed Nazi protection and a comfortable life in Berlin. Sam Apple, author of a new book, Ravenous, explores his remarkable tale of survival."" -- BBC History Revealed ""The research that Warburg is best known for today, and the work that forms the backbone of Ravenous, is his discovery that cancer cells behave differently from healthy cells in two very specific ways: They consume massive amounts of glucose — Apple compares them to ravenous shipwrecked sailors — and they eschew aerobic respiration in favor of fermentation... Apple covers everything from Hitler’s obsessive preoccupation with cancer to how the German Empire’s transformation into an industrial powerhouse led to a Romanticism-fueled movement that emphasized both environmental and racial purity. The fact that Apple can make these stories... feel so immediate is a testament to his canny knack for choosing apposite details."" -- Seth Mnookin - The New York Times ""Ravenous tells the story of an extraordinary life, and of the visionary work that sustained it... Apple has a gift for elegant analogies and illuminating similes… [An] exceptionally interesting and well-written book..."" -- Thomas Morris - Times Literary Supplement ""Eye-opening... filled with... outrageous and entertaining stories... I walked away from Ravenous thinking of Otto Warburg as a sort of Sigmund Freud of cancer research."" -- Sam Kean - The Wall Street Journal"

Author Information

Sam Apple has written for the New York Times Magazine, Wired, the Atlantic, and NewYorker.com. He is on the faculty of the MA in Science Writing and MA in Writing programs at Johns Hopkins.

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