Overview

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates. This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.

Full Product Details

Author:   Channing Der
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2006
Volume:   4
Dimensions:   Width: 16.00cm , Height: 2.10cm , Length: 24.00cm
Weight:   0.655kg
ISBN:  

9789048171101

ISBN 10:   9048171105
Pages:   397
Publication Date:   28 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Ras Stories: The State of the Art.- Ras-Gefs and Ras Gaps.- Structural Principles of Ras Interaction with Regulators and Effectors.- RAS and the RAF/MEK/ERK Cascade.- Noncanonical Effector Targets Of Oncogenic Ras Proteins.- Effectors of Ras-Mediated Oncogenesis.- RHO Proteins in RAS Signaling and Transformation.- Global Effects of Ras Signaling on the Genetic Program in Mammalian Cells.- Ras Signaling in C. Elegans.- Ras Family G-Proteins in Saccharomyces Cerevisiae and Schizosaccharomyces Pombe.- Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic Growth of Human and Rodent Cells.- Genetically Engineered Mice Harboring RAS Mutations as Models of Human Cancer: in Medias RAS.- Ras Family Proteins.- #x003BA;B-RAS: A Small Gtpase That Influences NF-#x003BA;B Signaling.- Anti-Ras Strategies for Cancer Treatment.

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