Randomised Response-Adaptive Designs in Clinical Trials

Author:   Atanu Biswas ,  Anthony C. Atkinson
Publisher:   Taylor & Francis Ltd
ISBN:  

9780367378974


Pages:   340
Publication Date:   04 November 2019
Format:   Paperback
Availability:   In Print   Availability explained
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Randomised Response-Adaptive Designs in Clinical Trials


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Overview

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

Full Product Details

Author:   Atanu Biswas ,  Anthony C. Atkinson
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.626kg
ISBN:  

9780367378974


ISBN 10:   0367378973
Pages:   340
Publication Date:   04 November 2019
Audience:   College/higher education ,  Tertiary & Higher Education
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

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Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science. Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.

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