Overview

Understand Quantitative Radiobiology from a Radiation Biophysics Perspective In the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses. Explore the Latest Cell Killing Numbers for Defining Iso-Effective Cancer Treatments The book compiles radiation mechanism information from biophysical publications of the past 50 years, addressing how ionizing radiation produces the killing of stem cells in human tumors. It presents several physical and chemical parameters that can modulate the radiation response of clonogenic cells in tumors. The authors describe the use of the LQ model in basic radiation mechanism studies with cells of relatively homogeneous radiation response and then extend the model to the fitting of survival data generated with heterogeneous cell populations (tumors). They briefly discuss how to use the LQ model for predicting tumor (local) control probability (TCP) and normal tissue complication probability (NTCP). The book also examines potential molecular targets related to alpha- and beta-inactivation and gives suggestions for further molecular characterizations of these two independent processes. Develop Efficacious, Patient-Friendly Treatments at Reduced Costs Focusing on quantitative radiobiology in LQ formulation, this book assists medical physicists and radiation oncologists in identifying improved cancer treatments. It also encourages investigators to translate potentially improved radiotherapy schedules based on TCP and NTCP modeling into actual patient benefit.

Full Product Details

Author:   J. Donald Chapman ,  Alan Nahum
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
ISBN:  

9781439862605

ISBN 10:   1439862605
Pages:   190
Publication Date:   15 April 2015
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Electronic book text
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Introduction The Generation of Quantitative Radiobiology Data Intrinsic Radiosensitivity of Proliferating and Quiescent Cells Effects of Ionization Density and Volume Ionizations along Charged-Particle Tracks The ABCs of Charged-Particle Radiotherapy The Frequency of Electron Track-Ends in Radiation Dose Impact of Fraction Size, Dose-Rate, Temperature and Overall Treatment Time on Tumor Cell Response Ionizing Events, Molecular Targets and Lethal Lesions Time-Scale of Radiation-Induced Cellular Damages and Their Expression The Oxygen Effect and Oxygen Enhancement Ratio (OER) Radiation Events-The Role of Energy Density and Ionization Volume The Molecular Target(s) for Cell Inactivation DNA Lesions Produced by Radiation in Cellular DNA The Radiosensitivity of Tumor Cells In Vitro versus In Vivo The Radiosensitivity of Cells Irradiated in Multicellular Spheroids The Radiosensitivity of Rodent Tumor Cells Appropriate Inactivation Parameters for Modeling Human Tumor Response Modern Radiobiology and the LQ Equation Molecular Biology Factors of alpha- and ss-Inactivation Low Dose Hypersensitivity (LDH) Bystander Effects Normal Tissues Radiobiology Information Derived from In Vitro Studies of Normal Tissue Cell Lines Therapeutic Ratio Fractionation Functional Subunits (FSUs) and the Volume Effect A Summary of the QUANTEC Study Radiobiology Applied to Tumor Response Modeling Epilogue References Index

Reviews

This book competently reviews the background science of the linear-quadratic (LQ) model with a clear mandate of applicability to clinical radiation oncology. These respected researchers and exceptional authors form the ideal team to implement radiobiological optimization. -Jerry J. Battista, PhD, Professor and Chair, Department of Medical Biophysics, Western University, London, Ontario, Canada ... synthesizes this complex field for contemporary practitioners in a highly useful and readable way. -Matthew B. Parliament, MD, Medical Director, Cross Cancer Institute, Alberta, Canada

Author Information

J. Donald Chapman provides consulting services to various radiation medicine commercial and academic organizations. His research has contributed to the fields of hypoxic radiosensitizing drugs, nuclear medicine markers of viable hypoxic cells, mechanisms of photodynamic therapy, and the killing of tumor cells by ionizing radiations. He has authored and co-authored over 200 articles in scientific journals and conference proceedings, served on the editorial boards of numerous radiation research journals, and received several international research awards. He earned a PhD in biophysics from the Pennsylvania State University. Alan E. Nahum is head of physics research at Clatterbridge Cancer Centre and a visiting professor in the Department of Physics at Liverpool University. His current research focuses on radiobiologically guided treatment optimization through the individualization of tumor prescription and fractionation. He has edited and co-edited three books, including Handbook of Radiotherapy Physics: Theory and Practice, and authored and co-authored approximately 170 peer-reviewed papers, book chapters, and conference proceedings. He earned a PhD in theoretical radiation dosimetry from the University of Edinburgh.

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