Overview

The radionuclides of iodine have the greatest versatility in labelling both hydrophilic and lipophilic compounds that are used in biology and medicine. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. A considerable amount of information on this topic is scattered through the literature; Dewanjee has gathered this and presents it in a systematic fashion, covering the period to 1990. On the basis of his experience in laboratories of nuclear physics, nuclear chemistry and radiochemistry, Dewanjee has produced a practical book, directed at readers ranging from basic scientists to clinicians and from students to experienced investigators. Each chapter begins with definitions and progresses to more comprehensive presentations of the disciplines of chemistry, biochemistry, molecular biology, physiology and pharmacology.

Full Product Details

Author:   Mrinal K. Dewanjee
Publisher:   Springer
Imprint:   Springer
Edition:   1992 ed.
Volume:   21
Dimensions:   Width: 15.50cm , Height: 3.40cm , Length: 23.50cm
Weight:   2.420kg
ISBN:  

9780792314912

ISBN 10:   0792314913
Pages:   621
Publication Date:   31 January 1992
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I: Introduction.- 1 History of Development of Iodine-Labeled Tracers.- 2 Physical Decay Characteristics of Radioisotopes of Iodine.- 3 Principles of Measurement of Radioiodinated Tracers and Related Instruments.- 4 Radiation Dosimetry of Iodine-Labeled Tracers.- 5 Hazards in the Handling of Radioiodine-Labeled Compounds and Central Facility for Radioiodination.- 6 Production of 131I, 125I and 123I Radionuclides and Their Separation From Targets.- II: Preparation of tracers.- 7 Chemistry of Radioiodination Reactions.- III: Localization of Tracers.- 8 Methods of Radioiodination Reactions with Several Oxidizing Agents.- 9 Mechanisms of Tracer Localization.- IV: Organ Imaging and tracer Applications.- 10 Radioiodinated Small Molecules and Their Applications.- 11 Radioiodinated Macromolecules.- 12 Applications of Radioiodinated Macromolecules.- 13 Radioiodinated Lipoproteins.- 14 Radioiodinated Peptides and Growth Factors and Their Applications.- 15 Miscellaneous Radioiodinated Polymers and Beads.- 16 Radioiodinated Haptens and Their Applications.- V: Purification of Substrate, quality control of tracers and Radiation damage during Storage.- 17 Preparation and Purification of Substrates and Proteins Before and After Radioiodination.- 18 Quality Control of Radioiodinated Products.- 19 Specific Activity and Radiation Damage in Tracers During Storage.

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