Overview

This book is an extension and major update of the author’s previous work, titled, “Practical Radiobiology for Proton Therapy Planning” (IOP 2018). The book describes the relative biological effectiveness (RBE) issues within proton therapy and advises on how to use a variable RBE within treatment planning and in dose prescription to improve the safety of proton and other forms on ion beam therapy. Decision-making advice is also provided for protocol breaches, retreatments, dose rate effects and risk assessment. This book is intended for those who already have basic knowledge of radiotherapy and radiobiology, although there is guidance through the fundamental principles for those who are ‘discipline crossing’. Key Features Provides coverage of key topics such as blood oxygen saturation, tissue oxygenation and respiration assessment. An extension and major update to “Practical Radiobiology for Proton Therapy Planning” by the author (IOP 2018). Brings thorough updates to each chapter, with the inclusion of more quantitative methods where appropriate. Contains end-of-chapter summaries; chapter problems; and simple experiments with pulse oximeters if the device is available. Includes Mathematica codes where appropriate.

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9780750362078

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Author Information

Bleddyn Jones, MD ScD FRCR, is an Emeritus Professor of Clinical Radiation Biology, University of Oxford. He has had over 40 years of interest and high impact research in neutron, proton and ion beam therapy and its associated radiobiology. He has made extensive contributions to the quantitative understanding of the relative biological effectiveness (RBE) of particle therapy from the ballistic properties to their cellular and tissue effects. This includes many practical applications based on specific clinical situations, to guide proton therapy to safer and more effective outcomes. Joshua Moore graduated in Mathematics at Cardiff University followed by a PhD in applied mathematics supervised by Dr Thomas E. Woolley primarily focusing on developing multiscale mathematical models to investigate organoid formation. His additional research interests are in applying mathematics in biological areas of sub-cellular dynamics, pattern formation, virology and oncology. Subsequently he has been appointed as a post-doctorate Research Associate in the Mathematical Institute at the University of Oxford.

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