Purinergic and Pyrimidinergic Signalling: Molecular, Nervous and Urogenitary System Function
Author:   Maria P. Abracchio ,  Michael Williams
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   Softcover reprint of hardcover 1st ed. 2001
Volume:   151 / 1
ISBN:  

9783642087424


Pages:   526
Publication Date:   01 December 2010
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Purinergic and Pyrimidinergic Signalling: Molecular, Nervous and Urogenitary System Function


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Overview

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

Full Product Details

Author:   Maria P. Abracchio ,  Michael Williams
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2001
Volume:   151 / 1
Dimensions:   Width: 15.50cm , Height: 2.80cm , Length: 23.50cm
Weight:   0.938kg
ISBN:  

9783642087424


ISBN 10:   3642087426
Pages:   526
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Purinergic Neurotransmission: An Historical Background.- 2 P1 Receptors.- 3 P2X Receptors.- 4 P2Y Receptors: Structure and Function.- 5 Purinergic Signalling in Development.- 6 Pl and P2 Purine and Pyrimidine Receptor Ligands.- 7 Regulation of Purine Release.- 8 Ecto-Nucleotidases.- 9 Role of Purines and Pyrimidines in the Central Nervous System.- 10 The Role of Purines in the Peripheral Nervous System.- 11 Trophic Roles of Purines and Pyrimidines.- 12 Nucleoside and Nucleotide Transmission in Sensory Systems.- 13 Roles of Purines in Nociception and Pain.- 14 Uridine and Pyrimidine Nucleotides in Cell Function.- 15 Purinergic Signalling in Lower Urinary Tract.

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