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Author:   Rossen Donev (Head of Research, MicroPharm Limited, UK)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.660kg
ISBN:  

9780443294105

ISBN 10:   0443294100
Pages:   318
Publication Date:   28 May 2025
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Accurate coarse grained models for protein association and recognition Agustí Emperador 2. In silico algorithms and computational methods to predict protein aggregation George Priya Doss Priya Doss C 3. Deciphering Protein Aggregation: Insights into Morphology, Contributing Factors, and Diseases Dileep Francis 4. Protein Aggregation in Cancer Disease Selvaraj Chandrabose Sr. 5. Tau protein aggregation: A therapeutic target for neurodegenerative disease Vijay Kumar Prajapati 6. Lipids modulates Tau protein aggregation Subashchandrabose Chinnathambi and Sreeramkumar Selvakumar 7. Heat shock proteins regulates Tau protein aggregation in AD Subashchandrabose Chinnathambi 8. Alpha-synuclein aggregation in Parkinson disease Edeildo Ferreira da Silva-Júnior 9. Understanding the impact of mutations on the structural stability and conformational landscape of LDB3 gene leading to protein aggregation myopathy: A high-performance Molecular Dynamics Simulation Study George Priya Doss Priya Doss C 10. Role of protein aggregates in bacteria Ewa Laskowska, Karolina Stojowska-Swedrzynska and Dorota Kuczynska-Wisnik 11. Molecular dynamics simulation directed the rational design of inhibitors for aggregation inhibition of SOD1 mutants related to amyotrophic lateral sclerosis (ALS) George Priya Doss Priya Doss C 12. Identification of New Non-Toxic Inhibitors of Insulin Fibril Formation and Preservatives for Insulin Preparations Oxana V. Galzitskaya, Sergei Grishin and Alexey Surin 13. Exploring therapeutic strategies based on chaperone-mediated disaggregation Edeildo Ferreira da Silva-Júnior 14. The Dual Facets of p53 and Its Paralogs: Aggregation and Phase Separation in Cancer Biology Jerson L. Silva 15. TBC Ferdinando Fiumara 16. Protein aggregation in health and disease: a looking glass of two faces Guilherme A. P. de Oliveira, Jerson L. Silva, Mayra Marques, Dinarte Moreira-Ferreira, Michelle Mota and Guilherme de Andrade 17. The aggregation propensity of Amyloid beta and Tau in Alzheimer's disease Subashchandrabose Chinnathambi, Murugappan Kumurappan, Madhura Chandrashekar and Sneha Malik 18. The cross-talk between ApoE and Tau protein in Alzheimer's disease Subashchandrabose Chinnathambi, Madhura Chandrashekar and Murugappan Kumurappan 19. Tau PET Probes for Alzheimer's Disease detection and their structural characterization Subashchandrabose Chinnathambi, Sneha Malik and Madhura Chandrashekar 20. Modifiable Chemical Risk Factors for Tau protein in Alzheimer's Disease Subashchandrabose Chinnathambi, Sneha Malik, Murugappan Kumurappan and Madhura Chandrashekar 21. Small molecule mediated therapeutic approaches to target Alzheimer's Disease Subashchandrabose Chinnathambi

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Author Information

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

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