Overview

Proteomics and Systems Biology, Volume 127 in the Advances in Protein Chemistry and Structural Biology series, outlines current proteomic methodologies and discuss the challenges in future applications of systems biology in a number of biomedical/bioscience subjects. In last few decades, advances in genomics, proteomics, metabolomics, glycomics, venomics, etc., have produced vast large-scale datasets that need to be analyzed with a single main objective of understanding biological systems as a whole. Such understanding will allow us to predict and characterize the dynamic properties of biological systems.

Full Product Details

Author:   Rossen Donev (Head of Research, MicroPharm Limited, UK) ,  Tatyana Karabencheva-Christova (Department of Chemistry, Michigan Technological University, Houghton, MI, USA)
Publisher:   Elsevier Science & Technology
Imprint:   Academic Press Inc
Weight:   0.750kg
ISBN:  

9780323853194

ISBN 10:   0323853196
Pages:   380
Publication Date:   23 July 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Using proteomic and transcriptomic data to assess activation of intracellular molecular pathways Anton Buzdin, Victor Tkachev, Marianna Zolotovskaia, Andrew Garazha, Sergey Moshkovskii, Nicolas Borisov, Nurshat Gaifullin, Maksim Sorokin, and Maria Suntsova 2. Proteomics in systems toxicology Carolina Madeira and Pedro M. Costa 3. Posttranslational modifications in systems biology Suruchi Aggarwal, Priya Tolani, Srishti Gupta, and Amit Kumar Yadav 4. Big data, integrative omics and network biology Priya Tolani, Srishti Gupta, Kirti Yadav, Suruchi Aggarwal, and Amit Kumar Yadav 5. Proteome analysis using machine learning approaches and its applications to diseases Abhishek Sengupta, G. Naresh, Astha Mishra, Diksha Parashar, and Priyanka Narad 6. Network-based strategies for protein characterization Alessandra Merlotti, Giulia Menichetti, Piero Fariselli, Emidio Capriotti, and Daniel Remondini 7. Proteomics and systems biology in optic nerve regeneration Sean D. Meehan, Leila Abdelrahman, Jennifer Arcuri, Kevin K. Park, Mohammad Samarah, and Sanjoy K. Bhattacharya 8. Proteomics of pseudoexfoliation materials in the anterior eye segment Jada Morris, Ciara Myer, Tara Cornet, Anna K. Junk, Richard K. Lee, and Sanjoy K. Bhattacharya 9. A systems biology approach to COVID-19 progression in population Magdalena Djordjevic, Andjela Rodic, Igor Salom, Dusan Zigic, Ognjen Milicevic, Bojana Ilic, and Marko Djordjevic 10. An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)—A systems biology approach 315 S. Udhaya Kumar, N. Madhana Priya, D. Thirumal Kumar, V. Anu Preethi, Vibhaa Kumar, Dhanushya Nagarajan, R. Magesh, Salma Younes, Hatem Zayed, and C. George Priya Doss 11. A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis S. Udhaya Kumar, Aisha Saleem, D. Thirumal Kumar, V. Anu Preethi, Salma Younes, Hatem Zayed, Iftikhar Aslam Tayubi, and C. George Priya Doss

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Author Information

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications. Dr. Tatyana Karabencheva-Christova works at the Department of Applied Sciences, University of Northumbria, UK.

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