Overview

Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name ""Proteome Research"", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.

Full Product Details

Author:   M. R. Wilkins ,  K.L. Williams ,  R. D. Appel ,  D. F. Hochstrasser
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   illustrated edition
Dimensions:   Width: 15.50cm , Height: 1.60cm , Length: 23.60cm
Weight:   0.408kg
ISBN:  

9783540627531

ISBN 10:   3540627537
Pages:   261
Publication Date:   April 2002
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Keith L. Williams, Denis F. Hochstrasser, Introduction to the Proteome.- Ben R. Herbert, Jean-Charles Sanchez, Luca Bini, Two-Dimensional Electrophoresis: The State of the Art and Future Directions.- Marc R. Wilkins, Andrew A. Gooley, Protein Identification in Proteome Projects.- Andrew A. Gooley, Nicolle H. Packer, The Importance of Protein Co- and Post-translational Modifications in Proteome Projects.- Amos Bairoch, Proteome Databases.- Ron D. Appel, Interfacing and Integrating Databases.- Manuel C. Peitsch, Nicolas Guex, Large-Scale Comparative Protein Modelling.- Denis F. Hochstrasser, Clinical and Biomedical Applications of Proteomics.- Keith L.Williams, Vitaliano Pallini, Biological Applications of Proteomics.- Denis F. Hochstrasser, Keith L.Williams, Conclusions.

Reviews

.,. describes the fundaments and backgrounds of the new technologies that are needed for large-scale protein analysis. This first book about the field of proteomics eloquently describes the fundamentals of the enabling technologies and is the ideal starting point to enter this new field. The authors show us how far this new field has evolved and where it may take us. BioWorld

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