Overview
In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called 'protease web', and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.
Full Product Details
Publisher: Elsevier Science & Technology
Imprint: Academic Press Inc
Weight: 0.610kg
ISBN: 9780323856966
ISBN 10: 0323856969
Pages: 308
Publication Date: 14 October 2021
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: Manufactured on demand
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Author Information
Dr. Andre Zelanis is Assistant professor of Proteomics and Systems Biology, and Head of the Functional Proteomics Laboratory at the Department of Science and Technology, Federal University of Sao Paulo, Sao Jose dos Campos, Brazil. His research focuses in proteomics and mass spectrometry-based approaches to uncover protease function in biological signaling pathways. Currently his lab is using proteomics to explore the repertoire of substrates (degradome) of proteases secreted by melanoma cells in culture and evaluating proteolytic processing events in the plasma of patients with metastatic melanoma. He has published widely in such peer reviewed journals as the Journal of Proteome Research and Comparative Biochemistry and Physiology.