Overview
This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena McGowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.
Full Product Details
Author: Ben Dunn (University of Florida, USA) ,
Ben Dunn ,
Mark Gorrell ,
Katja Fischer
Publisher: Royal Society of Chemistry
Imprint: Royal Society of Chemistry
Volume: Volume 18
Dimensions:
Width: 15.60cm
, Height: 2.40cm
, Length: 23.40cm
Weight: 0.585kg
ISBN: 9781849730495
ISBN 10: 1849730490
Pages: 292
Publication Date: 30 November 2011
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: In Print
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.
Reviews
The book thus certainly has the merit to broaden the perspective of readers and will be a good source of new information for those who are already to some degree familiar with research and drug discovery on proteinases and who want to dive deeper into the subject. The -- Dr. Richard Sedrani * ChemMedChem 2012, 7, 2040 – 2041 *
The book thus certainly has the merit to broaden the perspective of readers and will be a good source of new information for those who are already to some degree familiar with research and drug discovery on proteinases and who want to dive deeper into the subject. The -- Dr. Richard Sedrani ChemMedChem 2012, 7, 2040 - 2041
The book thus certainly has the merit to broaden the perspective of readers and will be a good source of new information for those who are already to some degree familiar with research and drug discovery on proteinases and who want to dive deeper into the subject. The -- Dr. Richard Sedrani * ChemMedChem 2012, 7, 2040 - 2041 *
The book thus certainly has the merit to broaden the perspective of readers and will be a good source of new information for those who are already to some degree familiar with research and drug discovery on proteinases and who want to dive deeper into the subject. The * ChemMedChem 2012, 7, 2040 – 2041 *
Author Information
Ben M Dunn is a Distinguished Professor of Biochemistry & Molecular Biology at the Department of Biochemistry & Molecular Biology, University of Florida, USA. He is also an NIH-funded Investigator and is currently supported by a MERIT award for the NIAID. He was President of the International Proteolysis Society from 2003-2005 and is currently President of the American Peptide Society.
