Overview

This volume presents a comprehensive overview on the drug discovery processes aimed at generating inhibitors for the treatment of malihnancies believed to be dependent on the gain of function of protein tyrosine kinases (RTKs). Specific topics include Src as a target for pharmaceutical intervention, JAK kinases in leukemias/lymphomas, platelet-derived growth factor, structural biology of PTKs, PI3-kinase inhibition, and phosphoproteomics in drug discovery and development.

Full Product Details

Author:   Doriano Fabbro ,  Frank McCormick
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2006 ed.
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.619kg
ISBN:  

9781588293848

ISBN 10:   158829384
Pages:   290
Publication Date:   01 September 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Protein Tyrosine Kinases as Targets for Cancer and Other Indications Mark Pearson, Carlos García-Echeverría, and Doriano Fabbro Inhibitors of Signaling Interfaces: Targeting Src Homology 2 Domains in Drug Discovery Carlos García-Echeverría PI3-Kinase Inhibition: A Target for Therapeutic Intervention Peter M. Finan and Stephen G. Ward Src as a Target for Pharmaceutical Intervention: Potential and Limitations Mira Susa, Martin Missbach, Rainer Gamse, Michaela Kneissel, Thomas Buhl, Jürg A. Gasser, Markus Glatt, Terence O'Reilly, Anna Teti, and Jonathan Green Activated FLT3 Receptor Tyrosine Kinase as a Therapeutic Target in Leukemia Blanca Scheijen and James D. Griffin JAK Kinases in Leukemias, Lymphomas, and Multiple Myeloma Renate Burger and Martin Gramatzki Glivec® (Gleevec®, Imatinib, STI571): A Targeted Therapy for Chronic Myelogenous Leukemia Elisabeth Buchdunger and Renaud Capedeville Platelet-Derived Growth Factor: Normal Function, Role in Disease, and Application of PDGF Antagonists Tobias Sjöblom, Kristian Pietras, Arne Östman, and Carl-Henrik Heldin Structural Biology of Protein Tyrosine Kinases Sandra W. Cowan-Jacob, Paul Ramage, Wilhelm Stark, Gabriele Fendrich, and Wolfgang Jahnke Testing of Signal Transduction Inhibitors in Animal Models of Cancer Terence O'Reilly and Robert Cozens Phosphoproteomics in Drug Discovery and Development Michel F. Moran, Jarrod A. Marto, Cynthia J. Brame, Olga Ornatsky, Mark M. Ross, Leticia M. Toledo-Sherman, Alfredo C. Castro, Brett Larsen, Henry Duewel, Christopher Hosfield, Christopher Orsi, Thodoros Topaloglou, Daniel Figeys, Jarrod A. Caldwell-Busby, and David R. Stover Index

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