Overview

This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.

Full Product Details

Author:   Thomas Böldicke
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2016
Volume:   917
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   6.215kg
ISBN:  

9783319328041

ISBN 10:   3319328042
Pages:   288
Publication Date:   06 June 2016
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction.- Part I Methods of Structure Prediction.- Chapter 1 In Silico Prediction of Target-Inhibitor Interactions.- Part II Antibodies.- Chapter 2 Antibodies and Selection of Monoclonal Antibodies.- Chapter 3 Selection of Recombinant Human Antibodies.- Chapter 4 Selection of Recombinant Human Antibodies against Toxins and Viruses.- Chapter 5 Recent Advances with ER Targeted Intrabodies.- Chapter 6 Therapeutic Blocking Antibodies against Oncogenic Receptors and Growth Factors.- Chapter 7 Synthetic Cystine-Knot Miniproteins-Valuable Scaffolds for Polypeptide Engineering.- Part III Peptides, Small Molecules and Aptamers.- Chapter 8 Peptides and Peptide Analogs to Inhibit Protein.- Chapter 9 Allosteric Modulators of the Class A G Protein coupled Receptors.- Chapter 10 Phosphatases: Their Roles in Cancer and their Chemical Modulators.- Chapter 11 Selection and Application of Aptamers and Intramers.- Part IV Angiogenesis Inhibitors.- Chapter 12 Inhibitors of Angiogenesis.

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