Overview

This volume summarizes over 20 years of research activity by the scientific community into the phenomenon of targeting proteins, the study of how newly synthesized proteins reach their ultimate destination. This may be an intracellular organelle such as the nucleus, mitochondria or rough endoplasmic reticulum, or it may be secreted or taken up by a cell and distributed to specific locations such as the endosome or lysosome. Small parts of the protein's structure are recognized by intracellular receptors, which direct or ""target"" the protein to its destination. Some proteins must cross membranes during this process, and many are subject to modification as they travel. The understanding of protein targeting has many applications, including cancer research, the study of diseases resulting from faulty targeting and the genetic manipulation of micro-organisms to target useful proteins.

Full Product Details

Author:   Brian M. Austen ,  Olwyn Westwood
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 15.00cm , Height: 0.60cm , Length: 23.00cm
Weight:   0.180kg
ISBN:  

9780199632176

ISBN 10:   0199632170
Pages:   95
Publication Date:   01 June 1991
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
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Table of Contents

Part 1 General principles: subcellular principles; targeting sequences and patches; cytoplasmic synthesis of proteins; the pathways that proteins take through cells; ways of identifying targeting sequences; evolutionary relationships in targeting; the role of targeting sequences in protein folding; the role of chaperone proteins. Part 2 Bacterial protein translocation: experimental approaches for determining protein localization; the structure of prokaryotic signal peptides; the membrane trigger hypothesis and M13 coat protein; components of the export machinery; translocation from the inner to the outer membrane; the novel secretion of haemolysin from Escherichia coli. Part 3 Protein translocation at the rough endoplasmic reticulum: historical background; the use of in vitro systems for studying protein translocation; structure and function of signal peptides; proteins involved in eukaryotic translocation; endoplasmic reticulum of yeast. Part 4 Assembly of membrane proteins: mode of attachment of proteins to membranes; topography of integral membrane proteins; mechanisms of assembly; hydrophobic modifications of proteins. Part 5 Protein sorting and motivation: regulated and bulk flow; export form the endoplasmic reticulum; glycosylation; budding and fusion of transport vesicles; sorting at the trans-Golgi network; endocytosis; sorting in polarized cells; alternative pathways of secretion. Part 6 Import of proteins from the cytosol: mitochondria; chloroplasts; peroxisomes; the nucleus.

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