Overview

This book covers elements of both the data-driven comparative modeling approach to structure prediction and also recent attempts to simulate folding using explicit or simplified models. Despite the unsolved mystery of how a protein folds, advances are being made in predicting the interactions of proteins with other molecules, such as small ligands, nucleic acids or other proteins. Also rapidly advancing are the methods for solving the inverse folding problem, the problem of finding a sequence to fit a structure. This book focuses on the various computational methods for prediction, their successes and their limitations, from the perspective of their most well known practitioners.

Full Product Details

Author:   Mohammed Zaki ,  Chris Bystroff
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2nd ed. 2008
Volume:   413
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.694kg
ISBN:  

9781588297525

ISBN 10:   1588297527
Pages:   337
Publication Date:   12 September 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface.- Contributors.- I: Overview of Protein Structure Prediction.- A Historical Perspective of Template-Based Protein Structure PredictionJun-tao Guo, Kyle Ellrott, and Ying Xu.- The Assessment of Methods for Protein Structure PredictionAnna Tramontano, Domenico Cozzetto, Alejandro Giorgetti, and Domenico Raimondo.- II: Template-based Methods.- Aligning Sequences to StructuresLiam James McGuffin.- Protein Structure Prediction Using ThreadingJinbo Xu, Feng Jiao, and Libo Yu.- III: Structure Alignment and Indexing.- Algorithms for Multiple Protein Structure Alignment and Structure-Derived Multiple Sequence AlignmentMaxim Shatsky, Ruth Nussinov, and Haim J. Wolfson.- Indexing Protein Structures Using Suffix TreesFeng Gao and Mohammed J. Zaki.- IV: Protein Features Prediction.- Hidden Markov Models for Prediction of Protein FeaturesBystroff and Krogh.- The Pros and Cons of Predicting Protein Contact MapsLisa Bartoli, Emidio Capriotti, Piero Fariselli, Pier Luigi Martelli, and Rita Casadio.- Road Map Methods for Protein FoldingMark Moll, David Schwarz, and Lydia E. Kavraki.- Scoring Functions for De Novo Protein Structure Prediction RevisitedShing-Chung Ngan, Ling-Hong Hung, Tianyun Liu, and Ram Samudrala.- Protein--Protein Docking: Overview and Performance AnalysisKevin Wiehe, Matthew W. Peterson, Brian Pierce, Julian Mintseris, and Zhiping Weng.- Molecular Dynamics Simulations of Protein FoldingAngel E. Garcia.

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