Overview

Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Full Product Details

Author:   Rossen Donev (Head of Research, MicroPharm Limited, UK) ,  Rossen Delete Donev (Swansea University, UK) ,  Rossen Delete Donev (Swansea University, UK) ,  Rossen Delete Donev (Swansea University, UK)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   83
Weight:   0.660kg
ISBN:  

9780123812629

ISBN 10:   0123812623
Pages:   312
Publication Date:   12 July 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Graphical representation and mathematical characterization of protein sequences and applications to viral proteins Ambarnil Ghosh and Ashesh Nandy Structural, thermodynamic and mechanistical studies in uroporphyrinogen III synthase. Molecular basis of congenital erythropoietic porphyria Arola Fortian, David Castaño, Esperanza Gonzalez, Ana Laín, Juan M. Falcon-Perez and Oscar Millet Role of Fibrin Structure in Thrombosis and Vascular Disease Amy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns Structural, Dynamic, and Functional Aspects of Helix Association in Membranes: a Computational View Anton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov Proteins MOVE! Protein dynamics and long-range allostery in cell signaling Zimei Bu and David J. E. Callaway Structural diversity of class I MHC like molecules and its implications in binding specificities Md. Imtaiyaz Hassan and Faizan Ahmad

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Author Information

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

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