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OverviewThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation. Full Product DetailsAuthor: Richard I. Morimoto , Yves ChristenPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: 2013 ed. Dimensions: Width: 15.50cm , Height: 0.80cm , Length: 23.50cm Weight: 0.454kg ISBN: 9783642447068ISBN 10: 3642447066 Pages: 136 Publication Date: 29 January 2015 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of ContentsThe Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto.- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron.- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin.- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen.- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo.- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima.- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl.- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner.- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri.- Subject code.ReviewsFrom the reviews: “This is a very good cutting edge book of scholarly import on the functioning of molecules and signal transduction in both neurodegeneration and neuroprotection. … I recommend this book highly to scientists in disease pathophysiology work.” (Joseph J. Grenier, Amazon.com, June, 2014) From the reviews: This is a very good cutting edge book of scholarly import on the functioning of molecules and signal transduction in both neurodegeneration and neuroprotection. ... I recommend this book highly to scientists in disease pathophysiology work. (Joseph J. Grenier, Amazon.com, June, 2014) Author InformationTab Content 6Author Website:Countries AvailableAll regions |