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Author:   Kevan M Shokat (Department Cellular and Molecular Pharmacology, University of California San Francisco, CA, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780123979438

ISBN 10:   0123979439
Pages:   496
Publication Date:   01 November 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Not yet available  
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Table of Contents

1. Catalytic Mechanisms and Regulation of Protein Kinases 2. The resistance tetrad: amino acid hotspots for kinome-wide design and exploitation of drug-resistant protein kinase alleles 3. Fragment-based approaches to the discovery of kinase inhibitors 4. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase ConformationsFLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations 5. The Logic and Design of Analog-sensitive (AS) Kinases and their Small Molecule Inhibitors 6. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs 7. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors 8. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate

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