Overview

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.

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9780323912877

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Dr. Md. Imtaiyaz Hassan, Ph.D., FRSB., FRSC., is Assistant Professor at the Centre for Interdisciplinary Research in Basic Sciences, in Jamia Millia Islamia, New Delhi, India. His research focuses on and design and development of potent and selective kinase inhibitors, as well as understanding the mechanism of folding and dynamic behavior of potential drug targets. Dr. Hassan has published widely in such peer reviewed journals as the International Journal of Biological Macromolecules, Spectrochimica Acta, Scientific Reports, and the OMICS A Journal of Integrative Biology. Dr. Saba Noor is a Research Associate at the Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India. Dr. Noor has expertise in molecular oncology, and her current research interests lie in development of kinase inhibitors for use in cancer therapeutics. She has published in such peer reviewed journals as Frontiers in Microbiology and International Journal of Biological Macromolecules, among other journals.

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