Overview

Since the publication of Protein Kinases in 1994 many novel protein kinases have been discovered, but perhaps more importantly there have been dramatic advances in our understanding of the cellular functions of this remarkably diverse class of proteins. Protein Kinase Functions is not just an update of the previous edition but provides a new focus on the context and function of protein kinases, thus reflecting the recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, the MAP kinase pathway, and cyclin-dependent kinases have been completely updated and new topics covered in depth are: phosphatidylinositol 3-kinase signalling, JAK-STAT signalling, suppression of tyrosine kinases by the SOCS family proteins, the TGFß superfamily, and the involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on the functional aspects of the whole system and the relationship between processes and molecules. It is the aim of Protein Kinase Functions to enable the reader to assimilate, compare, and integrate the molecular machinery used by cells to co-ordinate and respond to their environments.

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9780199637706

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One of the larger gene classes, protein kinases are the major players in most signal transduction pathways. Hence, the current volume, a series of reviews on types and functions, is timely. --Doody's<br> The prediction by Tony Hunter in 1987 ... that the human genome would encode 1001 protein kinases, which might have seemed incredible at the time, now looks remarkably close to the mark. ... If there are 1001 protein kinases, does this mean that they have 1001 different functions, which would make any attempt at a comprehensive description an extremely daunting task? Clearly, what is needed is a classification of their functions into groups or themes, where a description of the classic cases can serve as paradigms. This is what is attempted in this book. It is a second edition of Protein Kinases, first published in the Frontiers in Molecular Biology series in 1994 ... It is not a book of conference proceedings but a carefully chosen set of commissioned chapters. ... [T]he book is eminently suitable for graduate students and for those who have to teach this increasingly complex area. ... [and] can be thoroughly recommended to anyone interested in the field. --Trends in Cell Biology<br>

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