Overview

Written by outstanding scientists in physics and molecular biology, this book addresses the most recent advances in the analysis of the protein folding processes and protein structure determination. Emphasis is also placed on modelling and presentation of experimental results of structural membrane bound proteins.Many color plates help to illustrate structural aspects covered including:oDefining folds of protein domainsoStructure determination from sequenceoDistance geometryoLattice theoriesoMembrane proteinsoProtein-Ligand interactionoTopological considerationsoDocking onto receptorsAll analysis is presented with proven theory and experimentation.Protein Folds: A Distance-Based Approach is an excellent text/reference for biotechnologists and biochemists as well as graduate students studying in the research sciences.

Full Product Details

Author:   Henrik Bohr (Technical Univ. of Denmark) ,  Patrick Argos ,  Soren Brunak (Technical Univ of Denmark) ,  David S. Eisenberg
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 17.80cm , Height: 2.50cm , Length: 25.40cm
Weight:   0.839kg
ISBN:  

9780849340093

ISBN 10:   0849340098
Pages:   336
Publication Date:   20 October 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

. Introduction. Overview. Three Paradoxes of Protein Folding. Protein-Ligand Complexes and Protein Biosynthesis. Conserved Water Molecules and Protein Folding in Fungal Peroxidases. Interplay between Metal Coordination Geometry and Protein Structure. Elongation Factor Tu: A G-Protein in Protein Biosynthesis. Electron Transfer of the Di-Heme Protein: Pseudomonas stutzeri cytochrome c4,. Profile Methods for Protein Structure and Fold Determination. Sequence Matching in Homology Modelling. Screening Genome Sequences for Known Folds. Protein Fold Determination Using a Small Number of Distance Restraints. How Many Protein Fold Classes Are To Be Found? Distance-Based Protein Structure Prediction and Evaluation. The Effect of a Distance-Cutoff on the Performance of The Distance Matrix Error When Used as a Potential Function to Drive Conformational Search. Protein Structure Prediction: How Can Self-Misleading Be Avoided? Sequence Space Analysis: Identification of Functionally or Structurally Important Residues in Protein Sequence Families. Fitting 1-D Predictions into 3-D Structures. Determination of Membrane Bound Protein Structure and Function. Modelling a-helical Integral Membrane Proteins. Use of Small Organic Compounds and Metal-ions as Structural and Functional Probes in 7TM Receptors. Using Sequence Information and Model Building to Explore Subtype Specificity in GPCRs. Statistical Mechanics and Kinetics of Protein Folding Processes. Proposed Rules of the Protein Folding Game. Protein Folding Studied by Monte Carlo Simulations. Folding Kinetics of Protein Like Heteropolymers. Energy Landscape and Folding Mechanisms in Proteins. Topological Aspects of Protein Folds. Resonator Driven Protein Folding: The Implication of Topology for Protein Structure and Folding. Chirality in Protein Structure. Packing within and between Subunits Defined by Internal Cavities. Protein Modelling and Docking. Modelling and Predicting a-helical Transmembrane Structures. HIV GP120 Docking Interactions and Inhibitor Design Based on an Atomic Structure Derived by Molecular Modelling Using the DREIDING II Force Field. A Model of the 3D Structure of Obelin-The Photoprotein From Obelia longissima. Index. OTIs 7822, 2511, 4781

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Bohr\, Henrik; Brunak\, Soren

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