Overview

Covers the most recent advances in the field of protein folding and its impact on future technologies. Reviews in vivo aspects such as mechanisms of inclusion body formation and molecular chaperones, and includes highlights of Jonathan King's work at MIT. In vitro aspects examined include methods of protein folding, recovery of commercial protein products, and genetic approaches to understanding and solving protein folding problems. Written by leading scientists in the field, the volume provides a linkage between fundamental academic research and industrial applications of protein folding technology.

Full Product Details

Author:   Jeffrey L. Cleland
Publisher:   American Chemical Society
Imprint:   American Chemical Society
Volume:   526
Dimensions:   Width: 15.60cm , Height: 2.50cm , Length: 23.40cm
Weight:   0.529kg
ISBN:  

9780841226401

ISBN 10:   0841226407
Pages:   258
Publication Date:   01 January 1993
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   No Longer Our Product
Availability:   In Print  
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Table of Contents

Impact of Protein Folding on Biotechnology ; Amino Acid Sequence Determinants of Polypeptide Chain Folding and Inclusion Body Formation ; Duplicated Segment of Clostridium thermocellum Cellulases ; Probing the Role of Protein Folding in Inclusion Body Formation ; Experimental Investigation of the In Vivo Kinetics of Inclusion Body Formation ; Molecular Chaperones and Their Role in Protein Assembly ; Role of Molecular Chaperones in Transport of Proteins into the Mammalian Endoplasmic Reticulum: Solubilization-Achieving Proteins, Folding-Accelerating Proteins, and Translocation-Mediating Proteins ; Folding of Recombinant Human Insulin-Like Growth Factor-1 in Yeast ; Role of the Protein-Folding Chaperone BiP in Secretion of Foreign Proteins in Eukaryotic Cells ; GroEL-Mediated Protein Folding ; Prolyl Isomerizations as Rate-Determining Steps in the Folding of Ribonuclease T1 ; Kinetic Control of Protein Folding by Detergent Micelles, Liposomes, and Chaperonins ; Comparison of Amino Acid Helix Propensities (s-values) in Different Experimental Systems ; Single-Step Solubilization and Folding of IGF-1 Aggregates from Escherichia coli ; Role of Disulfide Bonds in Folding of Recombinant Human Granulocyte Colony Stimulating Factor Produced in Escherichia coli ; In Vivo Expression of Correctly Folded Antibody Fragments from Microorganisms ; Characterization of Humanized Anti-p185]H]E]R^2 Antibody Fab Fragments Produced in Escherichia coli ; Spectral Analysis of Site-Directed Mutants of Human Growth Hormone ; Altering the Self-Association and Stability of Insulin by Amino Acid Replacement

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