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Author:   Raphael Guerois ,  Manuela López de la Paz
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2006 ed.
Volume:   340
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.630kg
ISBN:  

9781588295859

ISBN 10:   1588295850
Pages:   300
Publication Date:   01 June 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Design of Structural Elementary Motifs.- Structure and Stability of the ?-Helix.- De novo Design of Monomeric ?-Hairpin and ?-Sheet Peptides.- De novo Proteins From Binary-Patterned Combinatorial Libraries.- Non-Protein Amino Acids in the Design of Secondary Structure Scaffolds.- Design and Synthesis of ?-Peptides With Biological Activity.- Design Of Entire Proteins And Protein Complexes.- Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds.- Consensus Design as a Tool for Engineering Repeat Proteins.- Multiple Sequence Alignment as a Guideline for Protein Engineering Strategies.- Sequence Search Methods and Scoring Functions for the Design of Protein Structures.- Prediction of Protein–Protein Interaction Based on Structure.- Electrostatic Design of Protein–Protein Association Rates.- Design of Amyloidogenic Polypeptides and Amyloid Inhibitors.- Peptide Model Systems for Amyloid Fiber Formation Design Strategies and Validation Methods.- Protein Misfolding Disorders and Rational Design of Antimisfolding Agents.

Reviews

.,. provides a comprehensive guide to the methods used at every stage of the protein-design process... - ChemBioChem <p>.,. combines a thorough theoretical foundation with detailed protocols and will be invaluable to all researchers in the area, from graduate students to senior investigators. -ChemBioChem

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