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Author:   Stefania Staibano
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 2013
Weight:   5.378kg
ISBN:  

9789402402353

ISBN 10:   9402402357
Pages:   296
Publication Date:   30 April 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases.- II Molecular pathology.- Molecular determinants of cancer-related inflammation.- Apoptosis and autophagy.- Androgen receptor and steroidogenesis pathways.- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy.- Metastatic dissemination.- Resistance to castration - resistance to drugs.- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer.- Gene polymorphisms.- Expression signature.- Mapping prostate cancer aggressiveness loci.- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models.- Targeting tumor angiogenesis.- Efficacy of signal transduction inhibition in advanced prostate cancer.- Therapeutic targeting of the bone pre-metastatic niche.- Counteracting hypoxia in radio-resistant metastatic lesions.- “Synthetic lethality”: molecular co-targeting to restore the DNA.- Repair mechanisms in prostate cancer cells concluding remarks. Index.

Reviews

From the reviews: A valuable compendium of salient topics in prostate cancer, this book encompasses the field, from diagnostic and prognostic criteria to current therapeutic approaches, while also offering valuable background in molecular pathology, genetics, and epigenetics. ... ideally directed to urologists aiming to learn more about the intricacies of prostate cancer at the cellular and molecular level as well as bench scientists and biologists with an interest in a comprehensive perspective on the disease. (Alessandro Fatatis, Doody's Book Reviews, January, 2014)

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