Progress in Medicinal Chemistry

Author:   David R. Witty (WITNET LTD, Cambridge, UK) ,  Brian Cox (Professor, University of Sussex, Brighton, UK)
Publisher:   Elsevier Science & Technology
Volume:   56
ISBN:  

9780444639394


Pages:   174
Publication Date:   20 March 2017
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Progress in Medicinal Chemistry


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Overview

Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators. Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs.

Full Product Details

Author:   David R. Witty (WITNET LTD, Cambridge, UK) ,  Brian Cox (Professor, University of Sussex, Brighton, UK)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Volume:   56
Weight:   0.440kg
ISBN:  

9780444639394


ISBN 10:   044463939
Pages:   174
Publication Date:   20 March 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Enabling Chemistry Technologies and Parallel Synthesis—Accelerators of Drug Discovery Programs S.W. Djuric, A.R. Bogdan, H.F. Koolman, Y. Wang and A. Vasudevan 2. Development of LRRK2 Inhibitors for the Treatment of Parkinson’s Disease K.V. Christensen, G.P. Smith and D.S. Williamson 3. Recent Progress in the Discovery and Development of TRPA1 Modulators S. Skerratt 4. Small Molecule Inhibition of Interleukin–1 Receptor-Associated Kinase 4 (IRAK4) N.E. Genung and K. Guckian

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Author Information

Dr David Witty has more than 20 years experience in the pharmaceutical industry as a medicinal chemist and project leader working principally in areas of anti-infectives, metabolic diseases, cognition and pain, delivering clinical candidates for several conditions. He led IT Strategy within the Neurology division of GSK, developing and deploying the first Electronic Notebooks for drug discovery to sites in the UK and Singapore. He has contributed more than 90 scientific papers, reviews, patents and books on medicinal and synthetic chemistry.In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. David presently leads their discovery programme and manages scientific operations within the business.David is chairman of the Fine Chemicals Group of the Society of Chemical Industry, with responsibility for the delivery of conferences, seminars and training courses for chemists throughout the UK and Europe, and advising parliamentary bodies on matters of relevance to the UK chemical industry.Since 2008 David has been a STEM ambassador for SETPOINT, introducing school students at both primary and secondary level to the excitement and possibilities of pursuing scientific careers, through workshops, lectures and competitions. Professor Brian Cox is at University of Sussex, Brighton, UK

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