Progress in Medicinal Chemistry

Author:   F.D. King (GlaxoSmithKline, Harlow, Essex, UK) ,  G. Lawton (St. Ippolyts, Herts, UK)
Publisher:   Elsevier Science & Technology
Edition:   45th edition
Volume:   45
ISBN:  

9780444528087


Pages:   232
Publication Date:   19 February 2007
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Progress in Medicinal Chemistry


Overview

The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

Full Product Details

Author:   F.D. King (GlaxoSmithKline, Harlow, Essex, UK) ,  G. Lawton (St. Ippolyts, Herts, UK)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Edition:   45th edition
Volume:   45
Dimensions:   Width: 14.00cm , Height: 1.40cm , Length: 21.00cm
Weight:   0.420kg
ISBN:  

9780444528087


ISBN 10:   0444528083
Pages:   232
Publication Date:   19 February 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface List of Contributors Hit and Lead Identification: Efficient practices for drug discovery DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes Recent Progress Towards Nonpeptide Ligands for the Melanocortin-4 Receptor Tuberculosis chemotherapy: recent developments and future perspectives Subject Index Author Index (Volumes 1-45) Subject Index (Volumes 1-45)

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Author Information

Dr Geoff Lawton has extensive experience in new medicine discovery across many therapeutic areas in both large and small companies and is a co-inventor of a marketed drug (Cilazapril). He is a former Director of Chemistry at Roche UK, and Vice-president Chemistry and Preclinical Sciences within Roche Bioscience, Palo Alto, USA. He was for five years the research member of a global therapy area strategy planning team for inflammatory diseases, aligning research with the clinical development and marketing parts of the business.From 2003 to 2007 he was founding Research Director with Lectus Therapeutics building from start-up a drug discovery organisation; generating the team, facilities and project portfolio targeting the next generation of ion channel modulating medicines. Since 2001 Geoff has provided scientific and strategic evaluation and advice on drug discovery as an independent consultant for a number small and medium sized biotech companies, CROs, VCs, academic groups and medical research charities. Geoff serves on the Board of Antabio, a French biotech company developing tomorrow’s antibacterial drugs.He is a founder of INMedD, a new medicines discovery social enterprise.

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