Overview

This book presents the latest research on DNA damage, which due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumour suppresser genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumour formation. The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. These modifications can in turn disrupt the molecules' regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. DNA is, however, supercoiled and wound around ""packaging"" proteins called histones (in eukaryotes), and both superstructures are vulnerable to the effects of DNA damage.

Full Product Details

Author:   Souta Miura ,  Shouta Nakano
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Edition:   illustrated edition
Weight:   1.100kg
ISBN:  

9781604565829

ISBN 10:   1604565829
Pages:   408
Publication Date:   01 October 2008
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Preface; Progress in Somatic Hypermutation Research; Factors Leading to the Induction and Conversion of DNA Damage into Structural Chromosomal Aberrations; Pesticides as Genetic Damage Inducers; DNA Damage Related to Exposure to Oil Spills: The Prestige Experience; Differentiated Cells Play Favorites: Dissecting the Mechanisms of Discrimination in DNA Repair; Functional Roles for Pro-Apoptotic Kinases on Nuclear Targeting and Induction of Apoptosis in Response to DNA Damage; Biological Significance of DNA Damage Checkpoint and the Mode of Checkpoint Signal Amplification; Cobalt Treatment Suppressing Mitochondrial DNA Damage Caused by Acute Exposure of H2O2; Molecular Basis of Guanine Oxidation Under UV-A/VIS Radiation and its Biological Effects; New Advances on DNA Fragmentation; Sperm Chromatin Damage; Sperm DNA Fragmentation in Assisted Reproduction; Comments on the Clinical Value of Determination of Sperm DNA Fragmentation; Assessing the Fast Micromethod as a Tool in DNA Integrity Analysis; Unconventional Use of the Comet Assay to Identify and Classify Different Nuclear Phenotypes in Cell Cultures; Bromodeoxyuridine-Labeling and DNA repair, When Studying Neurogenesis; Index.

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