Overview

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook.

Full Product Details

Author:   Shilpy Sharma (Assistant Professor at the Department of Biotechnology, Savitribai Phule Pune University, India)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   1.020kg
ISBN:  

9780128142592

ISBN 10:   0128142596
Pages:   442
Publication Date:   04 November 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. It is more than simple genes: The epigenome is more powerful than your genome 2. Diagnostic, prognostic and therapeutic potential of the inter-individual variability in the major epigenetic processes: A Clinical Prospective 3. Technological advances in studying epigenetics biomarkers for clinical research 4. DNA methylation and Chromatin remodeling: Potential prognostic biomarker for disease diagnosis 5. Use of post-translational histone modifications for disease diagnosis 6. Use of non-coding RNAs as Clinical Biomarkers for disease diagnosis 7. The Epigenetic Landscape in Neurological and Neurodegenerative Disorders 8. Epigenetic Biomarkers in Asthma and Allergy 9. Epigenetics Biomarkers in Metabolic syndrome and Obesity 10. Chromatin landscape and Epigenetic biomarkers for clinical diagnosis and prognosis of Type 2 Diabetes mellitus 11. Epigenetic biomarkers in Cardiovascular disorders 12. Epigenetic biomarkers in Cancer 13. Epigenetics in Infectious diseases 14. Epigenetics of autoimmune disorders 15. Epigenetics of Birth defects 16. Epigenetics of adverse pregnancy outcomes 17. Epigenetic landscape of Infertility 18.  Epigenetic landscape of polycystic ovarian syndrome 19. Epigenetic biomarkers in ocular disorders 20. Epigenetic biomarkers in personalized medicine 21. Conclusions and Perspectives. Future Challenges and Prospects for Prognostic Epigenetics and personalized epigenomics

Reviews

"""Several books in epigenetics exist in the literature, however, a good number of them provide only basic concepts. The value of this book is its provocative idea of utilizing epigenetic factors to reduce, modify, and/or treat human conditions. It provides a perfect link between the area of epigenetics and precision medicine."" --Doody"

Several books in epigenetics exist in the literature, however, a good number of them provide only basic concepts. The value of this book is its provocative idea of utilizing epigenetic factors to reduce, modify, and/or treat human conditions. It provides a perfect link between the area of epigenetics and precision medicine. --Doody

Author Information

Dr. Shilpy Sharma, PhD, is an Assistant Professor at the Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune) in Pune, Maharashtra, India. She has served as a Post-Doctoral Fellow in the Department of Pharmacology at University of Michigan and as a Post-Doctoral Fellow at the Department of Surgery, University of Chicago Medical Center. Dr. Sharma’s research focuses on identification of prognostic biomarkers for complex disorders including cancer, diabetes, and asthma; and infectious diseases.

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