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Author:   Kumar Gadamasetti ,  Tamim Braish ,  Klaus Muller (F. Hoffman-La Roche AG, Basel. Switzerland) ,  Tamim Braish
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   1.000kg
ISBN:  

9780367577599

ISBN 10:   0367577593
Pages:   538
Publication Date:   30 June 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever Changing Climate—An Overview. Emerging Trends in Process Chemistry. Varenicline: Discovery Synthesis and Process Chemistry Developments. The SUTENT® Story. An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist. Process Research and Development of LY414197, a 5HT2B Antagonist. To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant. Chiral Amine Synthesis—Strategies, Examples, and Limitations. The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862. Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals. The Lithium–Halogen Exchange Reaction in Process Chemistry. Oxetan-3-one: Chemistry and Synthesis. Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions. Toward Truly Efficient Organic Reactions in Water. The Chemical Development of the Commercial Route to Sildenafil Citrate. Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds. Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science. In Situ Mid-Infrared Spectroscopy for Process Development. Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Reaction. Development of Efficient One-Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism. Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend®). Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals—Promise, Practice, and Challenges. PEGylation of Biological Macromolecules. Microwave Technology in Process Optimization. Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture. Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps. Trends in Outsourcing. Sourcing Pharmaceutical Products in China and India. Index.

Reviews

"""The second installment in this progressive series, this volume reviews the latest breakthroughs to advance process chemistry . . . Jointly edited by the founder/ president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions by reputed scientists, technologists, engineers, and professors from leading academic institutions and from principal pharmaceutical companies influencing today’s market."" – In Anticancer Research, July/ August 2008, Vol. 28, No. 4A ""This is an excellent book . . . Overall this book is definitely recommended and the editors are to be congratulated on a job well done."" – In Scientific Update, 2008 ""This is an excellent book . . . this book is definitely recommended, and the editors are to be congratulated on a job well done."" – W. J. Watson, Scientific Update, in Organic Process Research & Development, October 2008, Vol. 30, No. 20"

The second installment in this progressive series, this volume reviews the latest breakthroughs to advance process chemistry . . . Jointly edited by the founder/ president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions by reputed scientists, technologists, engineers, and professors from leading academic institutions and from principal pharmaceutical companies influencing today's market. - In Anticancer Research, July/ August 2008, Vol. 28, No. 4A This is an excellent book . . . Overall this book is definitely recommended and the editors are to be congratulated on a job well done. - In Scientific Update, 2008 This is an excellent book . . . this book is definitely recommended, and the editors are to be congratulated on a job well done. - W. J. Watson, Scientific Update, in Organic Process Research & Development, October 2008, Vol. 30, No. 20

Author Information

Kumar Gadamasetti, Tamim Braish

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