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OverviewTransmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies. Full Product DetailsAuthor: Wen-Quan Zou , Pierluigi GambettiPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: 2nd ed. 2023 Weight: 1.370kg ISBN: 9783031205644ISBN 10: 3031205642 Pages: 793 Publication Date: 02 January 2023 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsPart I: HISTORY Chapter 1 Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek Paul Brown Part II: GENERAL ASPECTS OF PRIONS Chapter 2 The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein Glenn L. Millhauser Chapter 3 Mammalian Prion Structures Byron Caughey, Efrosini Artikis, and Allison Kraus Chapter 4 Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals Wen-Quan Zou Part III: CONVERSION AND STRAIN OF PRIONS Chapter 5 Prion Conversion and Deformed Templating Ilia V. Baskakov Chapter 6 Prion Strain Interference Ronald A. Shikiya and Jason C. Bartz Chapter 7 Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins Lenka Hromadkova, M. Khursheed Siddiqi, He Liu, and Jiri G. Safar Chapter 8 Cofactor Involvement in Prion Propagation Surachai Supattapone and Michael B. Miller Chapter 9 Prion Protein Conversion and Lipids Jiyan Ma and Xiangyi Zhang Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS Chapter 10 Prions in the Environment Shannon L. Bartelt-Hunt, Jason C. Bartz, and Qi Yuan Chapter 11 Environmentally Acquired Transmissible Spongiform Encephalopathy Paul Brown Chapter 12 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion Alexander H. Peden, Marcelo A. Barria Chapter 13 Species Barriers in Prion Disease Suzette A. Priola Part V: MODELLING OF PRIONS Chapter 14 Modeling the Cell Biology of Prions Richard Rubenstein, David Doyle and Robert B. Petersen Chapter 15 Transgenic Mice Modelling in Prion Diseases Barry Bradford, Neil A. Mabbott and Abigail B. Diack Chapter 16 Stem Cell Models in Prion Research Cathryn Haigh Chapter 17 Drosophila Models of Prion Diseases Ryan R. Myers and Pedro Fernandez-Funez Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES Chapter 18 Human Sporadic Prion Diseases Pierluigi Gambetti and Ignazio Cali Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases James A. Mastrianni Chapter 20 Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies Zerui Wang, Jue Yuan, Tricia Gilliland, Maria Gerasimenko, Syed Zahid Ali Shah, Wen-Quan Zou Chapter 21 The Spectrum of Tau Pathology in Human Prion Disease Gabor G. Kovacs and Herbert Budka Chapter 22 Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease Graham P. Roseman, Li Fu and Stephen M. Strittmatter Chapter 23 Prion and Cancers Wei Xin Chapter 24 Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury Zerui Wang and Wen-Quan Zou Part VII: ANIMAL PRION DISEASES Chapter 25 Bovine Spongiform Encephalopathy Gianluigi Zanusso and Salvatore Monaco Chapter 26 Classical and Atypical Scrapie in Sheep and Goats Christine Fast and Martin H. Groschup Chapter 27 Research models for studying chronic wasting disease Julianna Sun and Glenn Telling Part VIII: YEAST PRIONS Chapter 28 Introduction to Yeast and Fungal Prions Reed B. Wickner and Herman K. Edskes Chapter 29 Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems Reed B. Wickner, Herman K. Edskes, Moonil Son, Songsong Wu and Madaleine Niznikiewicz Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE Chapter 30 Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases Christina D. Orrù, Onyekachi Isiofia, Andrew G. Hughson and Byron Caughey Chapter 31 Protein Misfolding Cyclic Amplification Fabio Moda, Sandra Pritzkow, and Claudio Soto Chapter 32 Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases Zerui Wang, Johnny Dang, and Wen-Quan Zou Chapter 33 Diagnosis of Prion Disease: Conventional Approaches Inga Zerr and Peter Hermann Chapter 34 Human Prion Disease Surveillance Brian S. Appleby, Lawrence B. Schonberger, Ermias D. Belay Part X: TREATMENT Chapter 35 Overview on Treatment of Prion Diseases and Decontamination of Prions Richard Knight Chapter 36 Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases Manuel Camacho and Qingzhong Kong Chapter 37 Immunomodulation Thomas Wisniewski and Fernando GoñiReviewsAuthor InformationWen-Quan Zou, MD, PhD is Professor of Pathology at Case Western University School of Medicine, and he is Associate Director of the National Prion Disease Pathology Surveillance Center. Pierluigi Gambetti, MD, is Professor of Pathology and Neurology at Case Western University School of Medicine. Tab Content 6Author Website:Countries AvailableAll regions |
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