Overview

Leading researchers and clinicians describe their state-of-the-art findings and hypotheses arising from a variety of different approaches to this group of diseases. Their approaches include clinical presentations, epidemiology, transgenic methods, and diagnostic tests via transmission electron microscopy and immunoblotting. The diseases treated range from human to animal spongiform encephalopathies and include Creutzfeldt-Jakob disease, mad cow disease, and scrapie.

Full Product Details

Author:   Harry F. Baker ,  Rosalind M. Ridley
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1996 ed.
Volume:   3
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   1.480kg
ISBN:  

9780896033429

ISBN 10:   0896033422
Pages:   319
Publication Date:   17 April 1996
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

The Paradox of Prion Disease.- Human Spongiform Encephalopathy.- Neuropathological Diagnosis of Human Prion Disease.- Neuropathological Diagnosis of Human Prion Disease.- The Diagnosis of Bovine Spongiform Encephalopathy and Scrapie by the Detection of Fibrils and the Abnormal Protein lsoform.- Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies.- Surveillance of Prion Diseases in Humans.- Environmental Causes of Human Spongiform Encephalopathy.- Bovine Spongiform Encephalopathy.- Handling the BSE Epidemic in Great Britain.- Special Problems of Genetic Counseling in Adult-Onset Diseases.- Genotyping and Susceptibility of Sheep to Scrapie.- Strain Typing Studies of Scrapie and BSE.- PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies.- Transgenic Approaches to Prion “Species-Barrier” Effects.- Methods for Studying Prion Protein Amyloid.- Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems.- Immunohistochemistry of Resinated Tissues for Light and Electron Microscopy.

Reviews

Prion Diseases is a timely publication...Scientists already established in the subject as well as those embarking on such research for the first time will find the book useful. I also recommend it as a well structured text. - British Medical Journal

Prion Diseases is a timely publication...Scientists already established in the subject as well as those embarking on such research for the first time will find the book useful. I also recommend it as a well structured text..-British Medical Journal

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