Overview

Providing comprehensive coverage of methods and important issues in toxicology testing, this book begins with an introduction to the fundamental basics of toxicology, including principles of toxicokinetics, adsorption, distribution, metabolism, and the elimination of xenobiotics. It presents a detailed discussion of toxicity testing in animals and addresses contemporary issues such as high throughput screening, risk analysis, standardization, and validation. With drawings, figures, tables, and charts to facilitate understanding, this text also features a unique chapter on the interpretation of the significance of toxicity testing results with an examination of the ultimate purpose of testing.

Full Product Details

Author:   Frank A Barile
Publisher:   Taylor & Francis Inc
Imprint:   Productivity Press
ISBN:  

9781420008326

ISBN 10:   1420008323
Pages:   336
Publication Date:   December 2008
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Replaced By:   9781842145296
Format:   Electronic book text
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Basic Concepts in Toxicology Testing Introduction to Principles of Toxicology Types of Toxicology Common Terms and Nomenclature Applications of Toxicology Classification of Toxic Agents Sources of Toxins Effects of Chemicals Toxicological Effects Biochemical Properties Exposure Chemical Interactions Dose-Response Relationship Toxicokinetics Absorption Distribution Biotransformation Elimination Risk Assessment and Regulatory Toxicology Risk Assessment Regulatory Toxicology Descriptive Animal Toxicology Tests Correlation with Human Exposure Animal Welfare and U.S. Animal Welfare Act Chemicals Species Differentiation Methodologies Toxicology Testing In Vivo Acute Toxicology Testing Objectives of Acute Toxicology Tests LD50 and Acute Toxicology Tests Organization of Studies Range-Finding Tests Classical LD50 Other Considerations with LD50 Determinations Applications of LD50 Studies Subchronic and Chronic Toxicology Testing Types or Subchronic and Chronic Toxicity Tests Experimental Design Acute Dermal and Ocular Toxicology Testing Acute Dermal Toxicity Tests Acute Ocular Toxicity Tests Toxicology Testing for Fertility and Reproduction History and Development of Teratogenicity Testing Brief Description of Maternal-Fetal Physiology Mechanisms of Developmental Toxicity Teratogenicity Embryotoxicity Male Reproductive Toxicology Female Reproductive Toxicology Carcinogenicity and Mutagenicity Testing in Vivo Introduction and Definitions Multistage Carcinogenesis Carcinogenic and Genotoxic Agents Carcinogenicity Testing in Vivo Bioassay Protocols for in Vivo Carcinogenicity Testing Mutagenicity Testing in Vivo Toxicology Testing In Vitro Introduction to In Vitro Toxicology Testing History of in Vitro Methods In Vitro Systems History of Cell Culture Cell Culture Methodology Cell Culture Laboratory Cultured Cells Culture Requirements Procedures Cell Culture Methods for Acute Toxicology Testing Acute Target Organ Toxicity Testing Acute Local Toxicology Testing Toxicokinetic Studies in Vitro Metabolic Studies in Cell Culture Mutagenicity Testing in Vitro Bacterial Cell Systems Mammalian Cell Systems Development of Short-Term Test Strategies Reproductive and Teratogenicity Studies In Vitro Alternative Methods for Embryotoxicity Testing Validation of Alternative Methods for Reproductive and Teratogenicity Studies High Throughput Screening and Microarray Analysis High Throughput Screening in Preclinical Drug Testing Microarray Systems Experimental Design and Statistics Establishing Experimental Plan Experimental Design Hypothesis Testing and Statistical Applications Standardization and Validation of Alternative Methods Introduction Validation Process Current Validation Programs Applications of Alternative Models for Toxicology Testing Introduction Significance of Alternative Models for Animal Toxicology Testing Extrapolation to Human Toxicity Use of Alternative Methods for Human and Animal Toxicology Index

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