Overview

Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

Full Product Details

Author:   Daniel C. Chung ,  Daniel A. Haber
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2010
Weight:   0.855kg
ISBN:  

9781489977854

ISBN 10:   1489977856
Pages:   227
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Basic Principles of Cancer Genetics.- Principles of Cancer Genetic Counseling and Genetic Testing.- Genetics of Hereditary Breast Cancer.- Surgical Management of Hereditary Breast and Ovarian Cancer.- Hereditary Colon Cancer: Colonic Polyposis Syndromes.- Hereditary Colon Cancer: Lynch Syndrome.- Hereditary Pancreatic Cancer.- Hereditary Diffuse Gastric Cancer.- Familial Renal Cell Cancers and Pheochromocytomas.- Familial Atypical Mole Melanoma (FAMM) Syndrome.- Multiple Endocrine Neoplasia.- Pediatric Malignancies: Retinoblastoma and Wilms’ Tumor.- Neurofibromatosis and Schwannomatosis.- The HapMap Project and Low-Penetrance Cancer Susceptibility Alleles.- Somatic Genetic Alterations and Implications for Targeted Therapies in Cancer (GIST, CML, Lung Cancer).

Reviews

From the reviews: This thorough book outlines the most common genetic contributions to cancer and reviews cancer genetics and genetic counseling as well as recent advances in genome-wide association studies (GWAS) research and personalized medicine. ... a largely useful resource, particularly for students, residents, and entry-level clinicians in clinical cancer genetics. (Heather H. Wetzel, Doody's Review Service, August, 2010)

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