Overview

The result of the discussions of leading experts in the field of chemoprevention aimed at generating guidelines for the evaluation of putative strategies for chemoprevention for the forthcoming IARC Handbooks of Cancer Prevention. The resulting guidelines are presented in this book as a consensus document, alongside 27 authored papers dealing with topical issues in this exciting area of research.

Full Product Details

Author:   B. W. Stewart ,  etc. ,  D. McGregor (Unit of Carcinogen Identification and Evaluation) ,  P. Kleihues (Director, International Agency for Research on Cancer, Lyon)
Publisher:   International Agency for Research on Cancer
Imprint:   International Agency for Research on Cancer
Volume:   No.139
Dimensions:   Width: 17.00cm , Height: 1.50cm , Length: 24.00cm
Weight:   0.605kg
ISBN:  

9789283221395

ISBN 10:   9283221397
Pages:   370
Publication Date:   28 November 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

PCP/01 Role of chemoprevention in cancer control; PCP/02 Identifiability of food components for cancer prevention; PCP/03 Micronutrients (vitamins and minerals) as cancer-preventive agents; PCP/04 Retinoids as preventive agents; PCP/05 Vegetables, fruit and phytoestrogens as preventive agents; PCP/06 Aspirin and other nonsteroid anti-inflammatory drugs as cancer-preventive agents; PCP/07 Medicinal drugs with hormonal activity as chemopreventive agents; PCP/08 Intervention trials on colorectal cancer prevention; PCP/09 Chemoprevention trial on precancerous lesions of the stomach in Venezuela: summary of study; PCP/10 Adverse effects of preventive therapy in humans; PCP/11 Demonstration of organotropic effects of chemopreventive agents in the multi-organ; PCP/12 Inhibition of tumorigenesis in animals; PCP 13 Interaction of chemopreventive agents with hormone receptors; PCP/14 Modulation of the cytochrom P450 system as a mechanism of chemoprotection; PCP/15 Regulation of glutathione S-transferases and alduhyde reductase by chemoprotectors; PCP/16 Blocking the endogenous formation of N-nitroso compounds and related carcinogens; PCP/17 Mechanistic considerations in the evaluation of chemopreventive data; PCP/18 Micronutrients as chemopreventive agents; PCP/19 Use of carcinogen-DNA and carcinogen-protein adduct biomarkers for cohort selection and as; PCP/20 Molecular genetic alterations as intermediate end points in chemoprevention studies; PCP/21 (Information missing); PCP/22 Evaluation of human trial design; PCP/23 Evaluation of human trial findings; PCP/24 Tumour incidence reductions in carcinogenecity bioassays; PCP/25 Adducts to nuclear DNA and mitochondrial DNA as biomarkers in chemoprevention; PCP/26 Data evaluation as a contribution to cancer prevention; PCP/27 Interpretation of short-term test data: implications for assessment of chemopreventive; PCP/0 Preamble to the IARC Handbooks on the Evaluation of Cancer Preventive Agents

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