Overview

Practice Practice . Cell Biology Chapter 1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bon e as a Site of Metabolic Bone Activity Ego Seeman Chapter 2: Biomechanics of Bone Elise Morgan Chapter 3: Embr yonic Development of Bone and the Molecular Regulation of Intramembranou s and Endochondral Bone Formation Andrew Karaplis Chapter 4: Mesenchymal Stem Cells & Oste oblast Lineage Jane Aubin Chapte r 5: Transcriptional Control of Osteoblast Differentiation and Function Thorsten Schinke Ch apter 6: Wnt Signaling and Bone Mark Johnson Chapter 7: Sclerostin and Bone Rutger van Bezooijen Chapter 8: The Osteocyte Jenneke Klein-Nulend

Full Product Details

Author:   John P. Bilezikian (Columbia University, New York, New York, U.S.A.) ,  Lawrence G. Raisz (Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center) ,  T. John Martin (St. Vincent's Institute of Medical Research, Melbourne, Australia) ,  Lawrence G. Raisz (University of Connecticut, Farmington, U.S.A.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   3rd edition
Dimensions:   Width: 21.60cm , Height: 9.80cm , Length: 27.60cm
Weight:   5.340kg
ISBN:  

9780123738844

ISBN 10:   0123738849
Pages:   1900
Publication Date:   15 October 2008
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780128148419
Format:   Mixed media product
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Part I Basic Principles A. Cell Biology Chapter 1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Chapter 2: Biomechanics of Bone Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Chapter 4: Mesenchymal Stem Cells & Osteoblast Lineage Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Chapter 6: Wnt Signaling and Bone Chapter 7: Sclerostin and Bone Chapter 8: The Osteocyte Chapter 9: Cells of Bone: Osteoplast Generation Chapter 10: Osteoclast Function: Biology and Mechanisms Chapter 11: RANK Signaling Chapter12: Regulating Bone Resorption Chapter 13: Apoptosis in Bone Cells Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments B. Biochemistry Chapter 15: Type I Collagen: Structure, Synthesis, and Regulation Chapter 16: Collagen Crosslinking & Metabolism Chapter 17: Bone Matrix Proteoglycans & Glycoproteins Chapter 18: Osteopontin Chapter 19: Bone Proteinases Chapter 20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells Chapter 21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System C. Bone Remodeling and Mineral Homeostasis Chapter 22: Histomorphometric Analysis of Bone Remodeling Chapter 23: Phosphorus Homeostasis & Related Disorders Chapter 24: Magnesium Homeostasis Chapter 25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro Chapter 26: Biology of the Extracellular Ca2+-Sensing Receptor D. The Hormones of Bone Chapter 27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein Chapter 28: Parathyroid Hormone - Molecular Biology Chapter 29: Parathyroid Hormone-Receptor Interactions Chapter 30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System Chapter 31: The Vascular and Cardiovascular Actions of PTH Chapter 32: PTH and PTHrP Actions on Kidney and Bone Chapter 33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Chapter 36: Vitamin D Gene Regulation Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Chapter 39: Amylin and Calcitonin Gene-Related Peptide E. Other Systemic Hormones That Influence Bone Metabolism Chapter 40: Estrogens & Progestins Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Chapter 42: Mechanisms of Estrogen Action in Bone Chapter 43: Thyroid Hormone & Bone Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Chapter 45: Effects of Diabetetes & Insulin on Bone Physiology Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Chapter 47: Kinins & Neuro-Osteogenic Factors Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy F. Local Regulators Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Chapter 50: Platelet-Derived Growth Factor & the Skeleton Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Chapter 53: Transforming Growth Factor-a Chapter 54: Bone Morphogenetic Proteins and the Skeleton Chapter 55: Bone Morphogenetic Protein Receptors & Actions Chapter 56: Colony-Stimulating Factor-1 Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Chapter 58: Prostaglandins & Bone Metabolism Carol Pilbeam Part II Molecular Mechanisms of Metabolic Bone Disease Chapter 59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis Chapter 60: Molecular Basis of PTH Overexpression Chapter 61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism Chapter 62: Multiple Endocrine Neoplasia Type I Chapter 63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy Chapter 64: Local Factors in Skeletal Malignancy Chapter 65: Genetic Regulation of the Parathyroid Gland Development Chapter 66: Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations Chapter 67: Diseases Resulting from Defects in the G Protein Gs Chapter 68: Renal Osteodystrophy - Pathogenic Mechanisms and Therapeutic Options Chapter 69: Osteogenesis Imperfecta Chapter 70: Hereditary Deficiencies in Vitamin D Action Chapter 71: Oncogenic Osteomalacia Chapter 72: Osteopetrosis Chapter 73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans Chapter 74: Paget's Disease of Bone Chapter 75: Genetic Determinants of Bone Mass and Osteoporotic Fracture Chapter 76: Pathophysiology of Osteoporosis Chapter 77: Evaluation of Risk for Osteoporosis Fracture Part III Pharmacological Mechanisms of Therapeutics Chapter 78: Parathyroid Hormone Chapter 79: Calcium Chapter 80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics Chapter 81: Bisphosphonates: Mechanisms of Action Chapter 82: The Pharmacology of Estrogens in Osteoporosis Chapter 83: Vitamin D & Analogs Chapter 84: Estrogen Effects on Bone in the Male Skeleton Chapter 85: Mechanisms of Exercise Effects on Bone Quantity and Quality Part IV Methods in Bone Research Chapter 86: Application of Transgenic Mice to Problems of Skeletal Bone Chapter 87: Biochemical Markers of Bone Metabolism Chapter 88: Methods and Clinical Issues in Bone Densitometry Chapter 89: Controversial Issues in Bone Densitometry Chapter 90: Macro and Micro Imaging of Bone Architecture

Reviews

Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently. -The New England Journal of Medicine

PREVIOUS EDITION PRAISE Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently. --The New England Journal of Medicine

Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently. -The New England Journal of Medicine

Author Information

Dr. Bilezikian, Professor of Medicine and Pharmacology at the College of Physicians and Surgeons, Columbia University is the Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia-Presbyterian Medical Center. He also serves as Associate Chair, Department of Medicine. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians and Surgeons. He completed four years of house staff training (internship and residency) including the Chief Medical Residency of the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH where he served as a Clinical Associate in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies, including the American Society for Bone and Mineral Research, of which he served as President in 1996. He is a member of the Endocrine Society, the American Federation for Clinical Research, the American Society for Clinical Investigation, the Association of American Physicians, the American Association of Clinical Endocrinologists, the American Society for Pharmacology and Experimental Therapeutics, and the International Society of Clinical Densitometry, of which he is President. He is Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism. His books include Editor-in-Chief of The Parathyroids (1994), and co-editor of Principles of Bone Biology (1996), The Aging Skeleton (1999), and Dynamics of Bone and Cartilage Metabolism (1999). He has been on numerous panels, including serving as Chair of the NIH Consensus Development Panel on Optimal Calcium Intake, and the Food and Nutrition Board of the National Academy of Sciences. He is a major national and international spokesperson for the field of metabolic bone diseases. Dr. Bilezikian's major research inte Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.

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