Overview

The core text and standard reference in toxicology has once again been revised, updated, and expanded to incorporate the latest testing procedures and address the new challenges faced by toxicologists. Dr. Hayes has, once again, brought together more than 70 distinguished investigators to detail current testing procedures, offer guidelines on data interpretation, and highlight major areas of controversy. And once again, unlike its competitors, the book deals with the methods of toxicology as well as principles and agents. Virtually all the previous edition's chapters have been rewritten, and new chapters have been added on exposure assessment and epidemiology for toxicologists. You will find an in-depth look at the principles underlying toxicology, i.e., absorption, distribution, metabolism, and excretion, as well as topics dealing with pharmacokinetics. An excellent chapter on the history of toxicology starts the book. The second section describes many of the agents/chemicals found in the workplace and in the environment along with information on their untoward effects. The book allows the working toxicologist, whether a senior toxicologist or graduate student, to understand and use basic experiments in toxicology. Detailed protocols, including many of the pitfalls inherent in these experiments, are detailed in the third section. These experiments range from routine testing protocols to state-of-the-art techniques. The last section is new and contains a glossary of the important terms found in the book. In addition, each chapter has a series of questions that are designed to challenge the reader to rethink the contents of the chapter. Hayes; A Wallace The Gillette Company,

Full Product Details

Author:   A Wallace Hayes
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Edition:   4th New edition
Dimensions:   Width: 21.60cm , Height: 6.60cm , Length: 27.90cm
Weight:   3.243kg
ISBN:  

9781560328148

ISBN 10:   1560328142
Pages:   1912
Publication Date:   11 January 2001
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Replaced By:   9780849337789
Format:   Hardback
Publisher's Status:   Out of Stock Indefinitely
Availability:   Awaiting stock  

Table of Contents

The Art, the Science, and the Seduction of Toxicology: An Evolutionary Development. The Use of Toxicology in the Regulatory Process. Metabolism: A Determinant of Toxicity. Toxicokinetics: Pharmacokinetics in Toxicology. Physiologically Based Pharmacokinetic Modeling in Toxicology. The Toxicological Assessment of Pharmaceutical and Biotechnology Products. Statistics for Toxicologists. Quantitative Extrapolations in Toxicology. The Practice of Exposure Assessment. Epidemiology for Toxicologists. Food-Borne Toxicants. Solvents and Industrial Hygiene. Crop Protection Chemicals. Metals. Ionizing Radiation. The Use of Laboratory Animals in Toxicologic Research. Genetic Toxicology. Acute Toxicity and Eye Irritancy. Short-Term, Subchronic and Chronic Toxicology Studies. Principles of Testing for Carcinogenic Activity. Principles of Clinical Pathology for Toxicology Studies. Dermatotoxicology. Inhalation Toxicology. Detection and Evaluation of Chemically Induced Liver Injury. Renal Methods for Toxicology. Methods in Gastrointestinal Toxicology. Cardiovascular Physiology and Methods for Toxicology. Assessment of Male Reproductive Toxicity. Test Methods for Assessing Female Reproductive and Developmental Toxicology. Hormone Assays and Endocrine Function. Immunotoxicology: Effects of, and Response to, Drugs and Chemicals. Assessment of Behavioral Toxicity. Application of Isolated Organ Perfusion Techniques in Toxicology. Organelles as Tools in Toxicology. Analysis and Characterization of Enzymes and Nucleic Acids. Modern Instrumental Methods for Studying Mechanisms of Toxicology. Methods in Environmental Toxicology.

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