Primary Aldosteronism: Molecular Genetics, Endocrinology, and Translational Medicine
Author:   Per Hellman
Publisher:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2014
ISBN:  

9781493946228


Pages:   233
Publication Date:   23 August 2016
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Primary Aldosteronism: Molecular Genetics, Endocrinology, and Translational Medicine


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Overview

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

Full Product Details

Author:   Per Hellman
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2014
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   0.519kg
ISBN:  

9781493946228


ISBN 10:   1493946226
Pages:   233
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction.- Primary Aldosteronism: Molecular Mechanisms and Diagnosis.- Epidemiology and need for screening.- Low renin hypertension.- Molecular derangements in sporadic primary aldosteronism.- From genetic abnormalities to pathophysiological mechanisms.- Familial hyperaldosteronism type I.- Familial hyperaldosteronism type II.- Familial hyperaldosteronism type III.- The Aldosterone-renin ratio - role and problems.- Confirmatory testing for Primary Aldosteronism.- Radiological imaging of adrenocortical tumors.- Aldosterone and cardiovascular disease.- Quality of life aspects of primary aldosteronism.- Medical treatment of primary aldosteronism.- Surgical treatment of primary aldosteronism.- Index.

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