Overview

This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.

Full Product Details

Author:   Manfred Dietel ,  Christian Wittekind ,  Gianni Bussolati ,  Moritz Winterfeld
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2015 ed.
Volume:   199
Dimensions:   Width: 15.50cm , Height: 1.00cm , Length: 23.50cm
Weight:   3.376kg
ISBN:  

9783319139562

ISBN 10:   3319139568
Pages:   133
Publication Date:   10 March 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

What Is Pre-Analytics in Surgical Pathology? .- Histologic Validation of Vacuum Sealed Formalin.- Free Tissue Preservation and Transport System .- Pre-Analytics and Molecular Pathology.- Experiences in Vacuum Preparation of Routine Specimens.- Tissue Heterogeneity as a Pre-Analytical Source of Variability.- Vacuum Fixation of Breast Specimens Before Grossing.- How Do Short Fixation and Rapid Microwave Processing Affect Her2 Testing?.- Current Projects in Pre-Analytics – Where to Go?.- Nucleic Acid Extraction from FFPE Tissue as Critical Preanalytic Step for NGS Applications.- Experiences With Pre-Analytics of Lung Specimen.- Experiences With Pre-Analytics of GI-Specimen.- Bone Marrow Work-Up.- Two-Temperature Fixation Preserves Activation Status with High Efficiency.- Towards the Lean Lab. The Industry Challenge.  ​

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