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Author:   Gianfranco Pasut (Head of Pasut’s Protein and Drug Delivery Lab, Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy) ,  Samuel Zalipsky (Independent Pharmaceutical Drug Delivery and Biotechnology Consultant)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Weight:   1.060kg
ISBN:  

9780444640819

ISBN 10:   0444640819
Pages:   512
Publication Date:   31 October 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Introduction and General Aspects of the Technology 1. Evolution of Polymer Conjugation to proteins 2. PEGylated Proteins: A Rational Design for Mitigating Clearance Mechanisms and Altering Biodistribution 3. Overcoming barriers for tumor-targeted drug delivery: the power of macromolecular anticancer drugs with the EPR effect and the modulation of vascular physiology Toxicity and Immunogenicity Studies and Clinical Stage Conjugate Products 4. PEG-protein conjugates: Non-clinical and clinical toxicity considerations 5. Immunological responses to PEGylated proteins: anti-PEG antibodies 6. Immunogenicity assessment of PEGylated proteins, Lonquex, a PEGylated G-CSF case study 7. PEG-Protein conjugates: regulatory requirements for characterization 8. PEGylation of human coagulation factor VIII and other plasma proteins 9. Pegvorhyaluronidase Alfa: A PEGylated Recombinant Human Hyaluronidase PH20 for the Treatment of Cancers That Accumulate Hyaluronan 10. Challenges in the analytical characterization of PEGylated asparaginases Novel Site-Selective Methods of Conjugation 11. Glycan-targeted PEGylation for selective modification of proteins 12. Sialyltransferase mediated glycoPEGylation 13. Enzymatic approaches to new protein conjugates 14. Site-specific Polymer-protein conjugates by Cys mutation 15. Site-specific PEGylation of interferon beta-1b: from bench to clinic 16. Protein modification by bis-alkylation Alternative non-PEG polymers and architectures 17. In vivo properties of therapeutic bioconjugates composed of proteins and architecturally/functionally complex polymers 18. Poly(2-oxazoline)-protein conjugates 19. Polysaccharides for protein and peptide conjugation 20. Polysialylation of human coagulation factor VIII

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Gianfranco Pasut, PhD is Full Professor of Pharmaceutical Technology at the University of Padua and has more than 20 years of research experience in the field of drug and protein delivery, in particular by polymer conjugation. He is an author of more than 70 peer-reviewed publications and 14 book chapters on polymer conjugation and an inventor of 9 patents. His research lab investigates new approaches of polymer conjugation, ADC and targeted liposome preparations and pioneered and expanded the use of the enzyme transglutaminase for the development of new conjugates. Samuel Zalipsky, Ph.D. is currently an independent consultant in the areas of carrier mediated drug delivery, nanoparticles, biocompatible polymers, liposomes, preparation and applications of a wide spectrum of bioconjugates, and PEGylated biopharmaceuticals in particular. His professional tenure of over 30 years was spent mainly in pharmaceutical industry, contributing to several commercialized technologies and products. He is an author of over 90 publications and listed as an inventor on over 50 patents.

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