Overview

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease.  The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms.  This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients.  The final section covers current clinical trials and emerging therapies in PKD.  Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Full Product Details

Author:   Benjamin D. Cowley, Jr. ,  John J. Bissler
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2018
Weight:   5.332kg
ISBN:  

9781493977826

ISBN 10:   1493977822
Pages:   273
Publication Date:   25 May 2018
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

PART 1.  POLYCYSTIC KIDNEY DISEASE GENES & PROTEINS.- 1. Classical Polycystic Kidney Disease (PKD): Gene Structures and Mutations and Protein Structures and Functions.- 2. Bardet-Biedl Syndrome.- 3. Cystic Kidney Diseases Associated with Increased Cancer Risk: Tuberous Sclerosis Complex, Von Hippel Lindau, and Birt Hogg Dubé.- PART 2. POLYCYCSTIC KIDNEY DISEASE: MECHANISMS OF DISEASE.- 4. Aberrant Cellular Pathways in PKD.- 5. Cilia and Polycystic Kidney Disease.- 6. The Role of Inflammation and Fibrosis in Cystic Kidney Disease.- PART 3. CLINICAL FEATURES.- 7. Imaging-based Diagnosis of Autosomal Dominant Polycystic Kidney Disease.- 8. Renal Structural Involvement in Autosomal Dominant Polycystic Kidney Disease: Cyst Growth and Total Kidney Volume: Lessons from the Consortium for Radiologic Imaging of Polycystic Kidney Disease (CRISP).- 9. Renal Complications: Pain, Infection and Nephrolithiasis.- 10. ADPKD Extrarenal Manifestations: Polycystic Liver Disease.- 11. Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease.- PART 4. CLINICAL TRIALS AND EMERGING THERAPIES.- 12.  Role of Renin- Angiotensin- Aldosterone System Inhibition in Autosomal Dominant Polycystic Kidney Disease.- 13. Vasopressin Receptor Antagonism.- 14. End-stage Renal Disease in Patients with Autosomal Dominant Polycystic Kidney Disease.- 15. Polycystic Kidney Disease: Translating Mechanisms into Therapy Management of ADPKD Today.

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Author Information

John J. Bissler, MD Federal Express Chair of Excellence, Professor and Chief, Division of Nephrology, Department of Pediatrics, Director of the Tuberous Sclerosis Center of Excellence at Le Bonheur Children’s Hospital, Medical Director of Nephrology, St. Jude Children's Research Hospital, University of Tennessee Health Science Center University of Tennessee Health Science Center Children’s Foundation Research Center Memphis, TN  Benjamin D. Cowley, Jr., M.D., F.A.C.P., F.A.S.N. Professor of Medicine Chief, Nephrology & Hypertension John Gammill Professor in Polycystic Kidney Disease University of Oklahoma Health Sciences Center Oklahoma City, OK

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