Overview

The 7th International Symposium on Platinum and other metal coordination compounds in Cancer Chemotherapy, ISPCC '95, organized by the European Cancer Centre, was held in Amsterdam, the Netherlands, March 1-4, 1995. As with previous ISPCC meetings, the goal of ISPCC '95 was to bring together c1inicians, clinical investigators, scientists, and laboratory workers from many disciplines to promote further collaboration and cooperation in the development of new platinum and other metal coordination compounds as weil as in new ways to use 'c1assical' drugs as cisplatin and carboplatin in the treatment of cancer. Important aspects addressed by experts in the field inc1uded the synthesis and activity of new platinum compounds, the biochemistry and molecular pharrnacology as weil as the c1inical pharrnacology of this c1ass of antineoplastic agents, an overview of current c1inical studies, one special minisymposium on the mechanisms of cell kill of platinum, and one on resistance against platinum compounds. Finally, the current status of development of nonplatinum metal complexes was discussed. This volume contains the contributions of the various speakers at ISPCC '95 and provides an up-to-date and comprehensive overview of this important c1ass of anticancer agents, ranging from synthesis and molecular pharrnacology on one hand to c1inical pharrnacology and cIinical investigations on the other hand. The Organizing Corrunittee and Editors wish to express their gratitude to the contributors to this volume, to the various organizations and pharrnaceutical companies for their generous sponsoring of ISPCC '95, and to the Plenum Publishing Company for their help in producing this volume.

Full Product Details

Author:   Steef van de Velde ,  J.H. Schornagel
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   1996 ed.
Dimensions:   Width: 17.80cm , Height: 2.20cm , Length: 25.40cm
Weight:   2.040kg
ISBN:  

9780306452871

ISBN 10:   0306452871
Pages:   358
Publication Date:   30 April 1996
Audience:   College/higher education ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Synthesis and Activity of Platinum Compounds.- NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids.- Trans-Diamminedichloroplatinum (II) Is Not an Antitumor Drug: Why?.- Iminoethers as Carrier Ligands: A Novel trans-Platinum Complex Possessing in Vitro and in Vivo Antitumor Activity.- Molecular Dynamics Simulations on Cisplatin Adducts with Dinucleotides.- Orally Active DACH-Pt (IV) Compounds.- Clinical Pharmacology.- Pharmacokinetic — Pharmacodynamic Relationships.- Clinical Pharmacology of Carboplatin Administered in Alternating Sequence with Paclitaxel in Patients with Non-Small Cell Lung Cancer: A European Cancer Centre (ECC) Study.- The Clinical Development of the Oral Platinum Anticancer Agent JM216.- Biochemistry and Molecular Pharmacology.- Membrane Transport of Platinum Compounds.- Detection of Adducts Formed upon Treatment of DNA with Cisplatin and Carboplatin.- Detection of Platinum Lesions at the Nucleotide Level in Cells using Single Strand Ligation PCR.- A Review of the Modulation of Cisplatin Toxicities by Chemoprotectants.- Combination Therapy with Cisplatinum and EGF Receptor Blockade.- Clinical Studies.- Oxaliplatin: Update on a Active and Safe Dach Platinum Complex.- Combination of Different Platinum Compounds: Issues, Strategies and Experience.- Phase I and II Studies with Lobaplatin.- Phase I Trials of Ormaplatin (NSC 363812).- 254-S, NK121 and TRK710.- Clinical Trials of Oxaliplatin and DWA2114R.- Incorporating Assessments of Sequence-Dependence in Developmental Studies of Combination Chemotherapy Regimens Containing New Agents and Platinum Compounds.- Review of Carboplatin-Based High-Dose Chemotherapy Combinations in the Autotransplant Setting.- Treatment Intensification in Germ-Cell Tumours.- IL-1? Enhancement of Platinum-MediatedAnti-Tumor Activity.- Non-Platinum Metal Complexes.- Overview of Tumor-Inhibiting Non-Platinum Complexes.- How does Platinum Kill the Cell?.- The Cisplatin-Induced Cellular Injury Response.- The Interaction of Cisplatin with Signal Transduction Pathways and the Regulation of Apoptosis.- Cell Cycle Checkpoints and Cancer Chemotherapy.- Controversy Session: Cisplatin vs Carboplatin?.- Carboplatin versus Cisplatin in the Chemotherapy of Solid Tumors: Pro-Carboplatin.- Cisplatin and Carboplatin in Testis and Ovarian Cancer: Pro Cisplatin.- Resistance.- Hypersensitivity to Cisplatin in Mouse Leukemia L1210/0 Cells: An XPG DNA Repair Defect.- DNA Repair and the Carrier Ligand Specificity of Platinum Resistance.- Transcription Factor Differences in Cisplatin Resistant Cells.

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