Overview
The role of dopamine in schizophrenia has been a signficant area of research. The measurement of the major dopamine metabolite, homovanilic acid (HVA), in various body fluids, especially in blood plasma, is one of the primary methods to assess brain dopamine neuronal activity in living schizophrenic patients. Written by leading researchers in the field, this text provides a comprehensive collection of information on plasma HVA levels. It provides a concise synthesis and critique of data as well as proposals for future research. The book should be of value to any student of the biology of schizophrenia and other psychiatric disorders involving abnormal levels of plasma HVA.
Full Product Details
Author: Arnold J. Friedhoff, MD (New York University School of Medicine) ,
Farooq Amin, MD ,
Herbert Y. Meltzer
Publisher: American Psychiatric Association Publishing
Imprint: American Psychiatric Association Publishing
Dimensions:
Width: 15.20cm
, Height: 1.90cm
, Length: 22.90cm
Weight: 0.476kg
ISBN: 9780880484893
ISBN 10: 0880484896
Pages: 216
Publication Date: 02 March 1997
Audience:
College/higher education
,
Professional and scholarly
,
Undergraduate
,
Postgraduate, Research & Scholarly
Format: Hardback
Publisher's Status: Out of Print
Availability: Awaiting stock
Reviews
[I]t is a rich source of information for the specialist.... [T]his book will be valuable to all those working in the field of schizophrenia and related conditions, and would be a worthy addition to a departmental library. --The British Journal of Psychiatry
<p> The dopamine hypothesis continues to provide the principal conceptual gateway into the mysteries of schizophrenia. Therefore the measurement and dynamic assessment of HVA, the major metabolite of dopamine, offer opportunities for obtaining substantial understanding of dopamine's role in many diseases, of which schizophrenia is but one. Here in one convenient book, clinician and researcher alike can finally find the facts about plasma HVA and its central importance in the biology of schizophrenia. In this book, a compendium of contributions from many of the world's experts in biological psychiatry, the reader will find the most definitive, authoritative, and clearly written descriptions of the latest research on the usefulness of plasma HVA. These include treatment response to neuroleptics, the relation of this dopamine metabolite to the waxing and waning of positive symptoms and to schizophrenia-related conditions like schizotypal personality disorder, and carefully crafted critiqu
<p> The dopamine hypothesis continues to provide the principal conceptual gateway into the mysteries of schizophrenia. Therefore the measurement and dynamic assessment of HVA, the major metabolite of dopamine, offer opportunities for obtaining substantial understanding of dopamine's role in many diseases, of which schizophrenia is but one. Here in one convenient book, clinician and researcher alike can finally find the facts about plasma HVA and its central importance in the biology of schizophrenia. In this book, a compendium of contributions from many of the world's experts in biological psychiatry, the reader will find the most definitive, authoritative, and clearly written descriptions of the latest research on the usefulness of plasma HVA. These include treatment response to neuroleptics, the relation of this dopamine metabolite to the waxing and waning of positive symptoms and to schizophrenia-related conditions like schizotypal personality disorder, and carefully crafted critiques of current research and prescriptions for future research directions. This volume is a singularly important collection of seminal papers on a crucial aspect of the biology of schizophrenia that will inform all who are interested in diseases in which plasma HVA plays a role. -- Philip S. Holzman, Ph.D, Esther and Sidney R. Rabb Professor of Psychology, Emeritus, Harvard University, Cambridge, Massachusetts
The authors of this book make a good case for the measurement of plasma homovanillic acid as the best available approach to test theories concerning the role of DA in the etiology and treatment of schizophrenia. This volume brings together the leaders in this field of clinical research. Each chapter provides a thoughtful discussion of methodological issues and of new conceptualizations of psychotic states. The hypotheses presented in this book will be of great importance in our future understanding of schizophrenia. In addition, these studies provide information that leads to some interesting new speculations concerning the interactions between environmental forces, drug effects, and the dopamine system. I highly recommend this book to clinician and laboratory worker alike. -- John A. Harvey, Ph.D., Professor of Pharmacology and Psychiatry, Chief, Division of Behavioral Neurobiology, Department of Pharmacology, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania The dopamine hypothesis continues to provide the principal conceptual gateway into the mysteries of schizophrenia. Therefore the measurement and dynamic assessment of HVA, the major metabolite of dopamine, offer opportunities for obtaining substantial understanding of dopamine's role in many diseases, of which schizophrenia is but one. Here in one convenient book, clinician and researcher alike can finally find the facts about plasma HVA and its central importance in the biology of schizophrenia. In this book, a compendium of contributions from many of the world's experts in biological psychiatry, the reader will find the most definitive, authoritative, and clearly written descriptions of the latest research on the usefulness of plasma HVA. These include treatment response to neuroleptics, the relation of this dopamine metabolite to the waxing and waning of positive symptoms and to schizophrenia-related conditions like schizotypal personality disorder, and carefully crafted critiques of current research and prescriptions for future research directions. This volume is a singularly important collection of seminal papers on a crucial aspect of the biology of schizophrenia that will inform all who are interested in diseases in which plasma HVA plays a role. -- Philip S. Holzman, Ph.D, Esther and Sidney R. Rabb Professor of Psychology, Emeritus, Harvard University, Cambridge, Massachusetts [I]t is a rich source of information for the specialist.... [T]his book will be valuable to all those working in the field of schizophrenia and related conditions, and would be a worthy addition to a departmental library. -- The British Journal of Psychiatry
The dopamine hypothesis continues to provide the principal conceptual gateway into the mysteries of schizophrenia. Therefore the measurement and dynamic assessment of HVA, the major metabolite of dopamine, offer opportunities for obtaining substantial understanding of dopamine's role in many diseases, of which schizophrenia is but one. Here in one convenient book, clinician and researcher alike can finally find the facts about plasma HVA and its central importance in the biology of schizophrenia. In this book, a compendium of contributions from many of the world's experts in biological psychiatry, the reader will find the most definitive, authoritative, and clearly written descriptions of the latest research on the usefulness of plasma HVA. These include treatment response to neuroleptics, the relation of this dopamine metabolite to the waxing and waning of positive symptoms and to schizophrenia-related conditions like schizotypal personality disorder, and carefully crafted critiques of current research and prescriptions for future research directions. This volume is a singularly important collection of seminal papers on a crucial aspect of the biology of schizophrenia that will inform all who are interested in diseases in which plasma HVA plays a role. -- Philip S. Holzman, Ph.D, Esther and Sidney R. Rabb Professor of Psychology, Emeritus, Harvard University, Cambridge, Massachusetts
The dopamine hypothesis continues to provide the principal conceptual gateway into the mysteries of schizophrenia. Therefore the measurement and dynamic assessment of HVA, the major metabolite of dopamine, offer opportunities for obtaining substantial understanding of dopamine's role in many diseases, of which schizophrenia is but one. Here in one convenient book, clinician and researcher alike can finally find the facts about plasma HVA and its central importance in the biology of schizophrenia. In this book, a compendium of contributions from many of the world's experts in biological psychiatry, the reader will find the most definitive, authoritative, and clearly written descriptions of the latest research on the usefulness of plasma HVA. These include treatment response to neuroleptics, the relation of this dopamine metabolite to the waxing and waning of positive symptoms and to schizophrenia-related conditions like schizotypal personality disorder, and carefully crafted critiques of current research and prescriptions for future research directions. This volume is a singularly important collection of seminal papers on a crucial aspect of the biology of schizophrenia that will inform all who are interested in diseases in which plasma HVA plays a role. -- Philip S. Holzman, Ph.D, Esther and Sidney R. Rabb Professor of Psychology, Emeritus, Harvard University, Cambridge, Massachusetts The authors of this book make a good case for the measurement of plasma homovanillic acid as the best available approach to test theories concerning the role of DA in the etiology and treatment of schizophrenia. This volume brings together the leaders in this field of clinical research. Each chapter provides a thoughtful discussion of methodological issues and of new conceptualizations of psychotic states. The hypotheses presented in this book will be of great importance in our future understanding of schizophrenia. In addition, these studies provide information that leads to some interesting new speculations concerning the interactions between environmental forces, drug effects, and the dopamine system. I highly recommend this book to clinician and laboratory worker alike. -- John A. Harvey, Ph.D., Professor of Pharmacology and Psychiatry, Chief, Division of Behavioral Neurobiology, Department of Pharmacology, MCP Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania [I]t is a rich source of information for the specialist.... [T]his book will be valuable to all those working in the field of schizophrenia and related conditions, and would be a worthy addition to a departmental library. -- The British Journal of Psychiatry
Author Information
Arnold J. Friedhoff, M.D., is Menas S. Gregory Professor of Psychiatry and Director of the Millhauser Laboratories at the New York University School of Medicine in New York, New York. Farooq Amin, M.D., is Associate Chief of Psychiatry for Research at the Houston Veterans Affairs Medical Center and Director of Schizophrenia Research at the Baylor College of Medicine in Houston, Texas.
