Overview
By examining historical applications of the compounds found in plants, this five-volume series serves as a reference for quality assurance, research, product development, and regulatory guidance of the compounds found in plant-based medicines. This work supports the growing consumers' interest in herbal medicine for wellness and health. Plant-Based Therapeutics, Volume 1: Cannabis sativa, the first in the series, covers a unique plant species and provides the framework to integrate its evidence-based scientific discoveries with healthcare therapies. Cannabis has been used in religious ceremonies and medical purposes for thousands of years. Cannabidiol (CBD), the main non-psychoactive component of Cannabis, was isolated in the 1940s, and its structure was established in the 1960s. In 1964 tetrahydrocannabinol (THC), the psychoactive component, was isolated. Cannabis has more than 500 components, of which 104 cannabinoids have been identified. Two of them, THC and CBD, have been the primary components of scientific investigations. They were approved by the FDA for chemotherapy-induced nausea and vomiting in 1985; for appetite stimulation in wasting conditions, such as AIDS, in 1992, and in 2018 for treating two forms of pediatric epilepsy, Dravet syndrome and Lennox-Gastaut syndrome. Beyond the indications for which cannabinoids are FDA-approved, the evidence reveals that cannabinoid receptors are present throughout the body, embedded in cell membranes, and are believed to be more numerous than any other receptor system. When cannabinoid receptors are stimulated, a variety of physiologic processes ensue. Thus, other constituents of Cannabis are extremely promising either as individual compounds or their potential synergistic or entourage effects in the treatment of numerous medical conditions.
Full Product Details
Author: Ivan A. Ross
Publisher: Springer International Publishing AG
Imprint: Springer International Publishing AG
Edition: 2023 ed.
Weight: 1.178kg
ISBN: 9783031351549
ISBN 10: 3031351541
Pages: 657
Publication Date: 09 August 2023
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: Manufactured on demand 
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Table of Contents
Abbreviations Chapter 1 The History of Cannabis Botanical Description Origin and Distribution Chapter 2 The Bioactive Components of Plants Flavonoids Proteins and Peptides Glycosides Alkaloids Lignans Resins Saponins References Chapter 3 Chemical Constituents of Cannabis ReferencesChapter 4 The Bioactive Components of Cannabis The Endocannabinoid System The Entourage Effect of the Phytochemicals Biosynthetic Pathways Cannabinoid Receptors Endocannabinoids in the Circulation Endocannabinoids and Food Endocannabinoids and Body Mass Index Endocannabinoid and Circadian Rhythm Endocannabinoids and Exercise Endocannabinoids and Inflammation The Endocannabinoids and Stress Endocannabinoids and Chronic SNS or HPA Axis Activation Endocannabinoids in Reward, Anxiety, and Cognition Endocannabinoids and Cognitive Functions The Endocannabinoids and Pain Terpenes Phenols Trichomes Adverse Effects of Cannabinoids References Chapter 5 Neurological Effects of Cannabis Factors Affecting the Impact of Cannabis Use on the BrainErrors in Monitoring Awareness, Reward Processing, and Affective Processing Functional MRI Studies on Cannabis Endocannabinoid-Mediated LTP in Learning The Homosynaptic and Heterosynaptic eCB-Mediated Potentiation Memory and Cognitive Impairments Cannabis on Attention and Working Memory Cannabis and Spatial Working Memory Cannabis and Executive Function Neuropsychological Functioning in First-Episode Psychosis Cannabis and Olfactory Neuroepithelium Cells Cannabis and Audio/Visual/Verbal Memories Cannabis and Motor skills Cannabis and the Mismatch Negativity Cannabis and Traumatic Brain Injury The Cognitive and Emotional Impairments Induced by Carotid Artery Occlusion Relapse/Reinstatement of Drug-seeking Behavior Dysregulatory Risk Factor Cannabis and Driving Cannabis and Microglia Function Endocannabinoids and Astrocytes Cannabis and α2A-Adrenoceptor Cannabis and Catechol-O-Methyl Transferase Cannabis and Cyclooxygenase-2 Neurobiological Alterations during Pregnancy and Breastfeeding Cannabis in Adolescence Cannabis and Schizophrenia Cannabis and Bipolar Disorder Cannabis in Alzheimer's and Parkinson's Diseases Cannabis and Alcohol Consumption Cannabis and Tobacco Co-administration Medical vs. Recreational Cannabis Use Cannabis Flowers vs. Concentrate Acute Administration of Delta-9-THC vs. CBD Delta-9-THC vs. Delta-9-Tetrahydrocannabivarin Delta-8-THC vs. Delta-9-THC Drug Addiction Cannabinoids and Pain Cannabis and Gender Differences Cannabis and HIV Cannabis on Heart Rate and EEG The Residual Impact of Cannabis Therapeutic Perspectives References Chapter 6 Psychotropic Effects of Cannabis Structural and Functional Effects of Cannabis on the Brain Cannabinoids on Physical and Mental Health Cannabinoids in the Pathophysiology of Psychosis The Endocannabinoid System and HPA Axis Regulation Cannabis and Auditory Evoked Mismatch Negativity Cannabis on Cognitive Performance Delta-9-Tetrahydrocannibidiol and Psychosis The Anti-psychotic Properties of Cannabidiol First Episode Psychosis Cannabidiol on Anxiety, Depression, and Psychosis Bipolar Disorder Addictive and Psychiatric Comorbidity Motor and Cognitive Impairments Schizotypal Personality Disorder Implicit and Explicit Psychotic Disorders Delta-9-THC and CDB on Cognitive Functions Psychosis and Schizophrenia Dependence and Behavioral Disturbances Cannabis and Pregnancy Cannabis and the Vulnerable Adolescent Group Post-traumatic Stress Disorder Schizophrenia-like Psychoses Cannabis and Psychosocial Stress Synthetic Cannabinoids Cannabidiol and Parkinson’s Patients Metabolic Dysregulation Creatine Kinase Elevation The Cardiac Electrophysiological Effects of Cannabidiol References Chapter 7 The Analgesic effects of Cannabis Routes of Administration Modulation of Chronic Neuropathic Pain Pathological or Injury-related Persistent Pain The Antinociceptive Effects of Delta-9-THC Terpenes in Cannabis-mediated Analgesia Co-administration of Cannabis and Opoid Cannabidiol and the Serotonin (5-HT)1A Receptor TRPV1 as a Target of the Therapeutic Potential of Myrcene Cannabinoids and the Glycine Receptors Gender Differences in Cannabinoid-mediated Antinociceptive Effects Cannabidiol and Osteoarthritis Rheumatologic Pain Cannabis in Acute Pain and Hyperalgesia The Endocannabinoid System and Integumentary Wounds The Endocannabinoid System in Female Reproduction The Cannabis Flower in Pain Management Cannabis in Capsaicin-induced Pain Cannabis use Pre-operatively Cannabis and Post-operative Pain The Tetrad Effects - Analgesia, Hypothermia, Catalepsy, and Suppressed Locomotion Stress-induced Ulcerogenesis Cannabis and the Psychotropic Side Effects in Migraine Pain Capsaicin in Cannabinoid Hyperemesis The Analgesic Effects of MAGL and FAAH Inhibitors The Endocannabinoid System and Glutamate N-Methyl-D-Aspartate Synthetic Cannabinoids on the Visual, Auditory, and Tactile Responses Spasticity in Multiple Sclerosis Cannabis in Amyotrophic Lateral Sclerosis Cannabis in Takotsubo Cardiomyopathy References Chapter 8 Cannabis and Perinatal DevelopmentEye Disorders in Infants Prenatally Exposed to Opioids, Cocaine, and Cannabis Adverse Neonatal Outcomes Neonatal Withdrawal Syndrome Cannabis during Lactation Adult Working Memory Cannabinoid Hyperemesis Syndrome Cannabis, Tobacco, Alcohol, and Cocaine Modes of Cannabis Administration Stressful Life Events and Cannabis Use The Demographics of Cannabis Consumption The Association of Prenatal Substance use with Prenatal and Postpartum Care Patterns of Maternal Cannabis use Predicted Offspring Substance Use Encephalograms in Prenatal Exposure to Cannabis Cannabis and Children’s Dental Health Cannabis and Maternal Choline Cannabis and Tobacco Use Maternal and Paternal Tobacco and Cannabis Use Cannabis use and Fetal Birth Weight Cannabis and Tobacco Use Prenatal Cannabis Exposure Development and Infancy Study of Prenatal Drug Use The Genetics of Cannabis use Behavior The Impact of Cannabis Laws on Cannabis Use The Health Effects of Cannabis and Cannabinoids Physiological and Neurodevelopmental Outcomes of Cannabis Exposure Genetic Involvement in Cannabis Exposure Cannabinoids and the Immune System Cannabis use and the Perception of the User during Pregnancy Maternal Age and Cannabis Use Pregnancy Risk Assessment Cannabis in Nausea and Vomiting During Pregnancy Parental Cannabis use on Child Development Prenatal Tobacco and Co-exposure to Tobacco and Cannabis Prenatal Exposure to Alcohol and Delta-9-THC Prenatal Tobacco, Alcohol, and Cannabis Exposures Prenatal Exposures to Adult Electronic Cigarette Prenatal Cannabis Exposure on Emotional, Social, and Cognitive Endpoints Cannabis and Prenatal Choline on Fetal Brain Development In Utero Exposure to Cannabis, Tobacco, and Cocaine Cannabis use Late in Pregnancy Infant Neurobehavioral Development Tobacco and Cannabis Exposure on Child Behavior Problems The Hypothalamic/Pituitary/Adrenal Axis Somatometric Alterations and Risk Factors Child Maltreatment and its Association with Cannabis Use Prenatal Cannabis Exposure and Transport-related Injuries Postpartum Exposure to Cannabis and Tobacco on Immune Function References Chapter 9 Cannabis and Multiple Sclerosis The Endocannabinoid System and MS Cannabigerol in Multiple Sclerosis Cannabis for Spasticity Symptoms and Neuropathic Pain Cannabis-based Treatments for Tremors Cannabis and Cognitive Impairment Cannabis on Processing Speed, Memory, and Executive Functioning Acute Effects of Cannabis Use Chronic Effects of Cannabis Use Structural and Functional Abnormalities in Young Cannabis Users The Effects of Cannabis on Serum Cytokines Cannabis Consumption and Urinary Functions Glucose Uptake and Cognitive Functions in Multiple Sclerosis Physical and Psychological Impact Cannabis Cannabis Use in Depression Pain Management in MS Immunomodulatory Effects of Cannabinoids Cannabis and Cytochrome P450 Anti-inflammatory Effects of Cannabidiol Risk Factors of Multiple Sclerosis ReferencesChapter 10 Cannabis and Cancer Endocannabinoids and Cancer Cannabinoids and Cancer Cell Cycle Progression Autophagy and Apoptosis Angiogenesis Cytotoxicity Pancreatic Cancer Glioblastoma, Glioma, and Neuroblastoma Lung Cancer Urogenital Cancer Hodgkin’s Lymphoma Prostate Cancer Myeloma Oral Cancer Colorectal Cancer Melanoma Hepatocellular Carcinoma Endometrial and Cervical Cancers Breast Cancer Bone Cancer Leukemia Cannabis and Tobacco Cannabis in Immunotherapy Cannabis and Radiation Therapy References Chapter 11 Cannabis and Parkinson’s disease The Endocannabinoid System and Parkinson’s disease Cannabinoids and Parkinson's disease Cannabis Use and Dopaminergic Gene Polymorphism Parkinson's disease and Complementary Therapies Synthetic Cannabinoids and Parkinson’s disease Opiates and Parkinson's disease Morphine and Parkinson's disease Cocaine and Parkinson's disease Amphetamines and Parkinson’s disease Innovative Therapies in Parkinson’s disease References Chapter 12 Cannabis and the Skin Keratinocyte Proliferation Melanocytes Kaposi's sarcoma Psoriasis Acne Vulgaris and Seborrhea Alopecia and Hair Growth Disorders Pruritus Atopic Dermatitis Allergic Contact Dermatitis Systemic Sclerosis Cutaneous Melanoma Dermatomyositis Cutaneous Lupus Erythematosus Epidermolysis Bullosa Wound Healing and Skin AgingReferences Chapter 13 Antiviral Activities of Cannabis Immune Response Hepatitis Virus Herpes Simplex Virus Human Immunodeficiency Virus Influenza Virus Coronavirus References Chapter 14 Alkaline Phosphatase Stimulation CDB and Methylsulfonylmethane Cannabis and Alcohol Co-administration Cannabis and β-Carotene Cannabis and Dill Seeds on Gut Health Cannabis and Physical Health Cannabidiol for Enhancing Osteoblastic Differentiation Cannabis and Spermatogenesis Cannabidiol and Liver Tests Cannabidiol and Sublesional Bone Loss Delta-9-THC and the Anticancer Drug Irinotecan References
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Ivan A. Ross, Biologist (Ret'd), U.S. Food and Drug Administration (FDA), participated in planning and conducting toxicology research projects and related programs and policies to ensure they meet the needs of the United States of America's food programs and responsibilities. He also developed, validated, and documented state-of-the-art analytical methods for specific specimens, compounds, or classes of compounds as necessary for increased efficiency and assurance of accuracy. Dr. Ross has published several research articles and four volumes of reference books, Medicinal Plants of the World: Chemical Constituents, Traditional, and Modern Medicinal Uses with Humana Press (now a Springer Imprint).
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