Overview

Genomics has fundamentally altered the way in which we view plant biology, by providing the possibility of taking a global view of cellular processes. Sequencing programs are rapidly documenting the expressed genes of many species, but the big question is what do these genes do? This volume investigates the different approaches to analysing plant gene function, centring on the role of phytochemistry in the rapid developments in biology brought about by the application of large-scale genomics approaches. Several functional genomic approaches discussed in this volume, address plant gene function on a large scale. Plants are combinatorial chemists par excellence, and understanding the principles that relate enzyme structure to function will open up unlimited possibilities for the rational design of new enzymes to generate novel biologically-active natural products. Knowledge of the molecular genetics of plant natural product pathways will also facilitate the engineering of these pathways for plant improvement and human benefit. Phytochemistry has a great future in the genomics and post-genomics eras. Contributors to this volume explore a wide range of topics that include: bioinformatics and computational biology; metabolite profiling; metabolomics as a component in functional genomic studies; biopanning by activation tagging; functional genomics of Cytochromes P450 and their role in biosynthesis; sequence-based approaches to alkaloid biosynthesis gene identification; and structurally guided alteration of biosyntheses.

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9780080441160

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