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Author:   F. Javier Alvarez-Leefmans, MD, PhD (Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, USA) ,  Eric Delpire (Vanderbilt University, Nashville, Tennessee, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.60cm , Height: 3.80cm , Length: 27.60cm
Weight:   2.300kg
ISBN:  

9780123743732

ISBN 10:   0123743737
Pages:   630
Publication Date:   22 August 2009
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Section I Overview of chloride transporters and channels 1. Chloride Channels: An Historical Perspective by H. Criss Hartzell 2. Sodium-Coupled Chloride Cotransporters: Discovery and Newly Emerging Concepts by John Russell 3. Pathophysiology of the K+-Cl- Cotransporters: Paths to Discovery and Overview by John S. Gibson, J. Clive Ellory, Norma C. Adragna and Peter K. Lauf 4. From Cloning to Structure, Function, and Regulation of Chloride-dependent and Independent Bicarbonate Transporters by Michael F. Romero, Min-Hwang Chang and David Mount 5. Thermodynamics and Kinetics of chloride transport in Neurons: An Outline by F. Javier Alvarez-Leefmans and Eric Delpire Section II Current methods for studying chloride regulation 6. Chemical and GFP-based Fluorescent Chloride Indicators by Alan S. Verkman 7. Clomeleon, a Genetically-encoded Chloride Indicator by Ken Berglund, Thomas Kuner and George J. Augustine 8. Gramicidin Perforated Patch by Norio Akaike 9. Measuring Electroneutral Chloride-dependent Ion Fluxes in Heterologous Expression Systems by Kenneth Gagnon 10. Knockout models of cation chloride cotransporters by Nicole Garbarini and Eric Delpire Section III From cloning to structure, function and regulation of chloride channels 11. The NKCC and NCC genes: An in silico view by Mauricio Di Fulvio and F. Javier Alvarez-Leefmans 12. The ClC Family of Chloride Channels and Transporters by Tobias Stauber, Gaia Novarino and Thomas J. Jentsch 13. Calcium-Activated Chloride Channels by Fiona Britton, Normand Leblanc and James L. Kenyon 14. GABAA Receptor Channels by Robert L. Macdonald and Emmanuel J. Botzolakis 15. The Puzzles of Volume-Activated Anion Channels by Yasunobu Okada, Kaori Sato, Abduqodir H. Toychiev, Makoto Suzuki, Amal K. Dutta, Hana Inoue and Ravshan Z. Sabirov 16. The Sodium-Dependent Chloride Cotransporters by Gerardo Gamba 17. The Potassium-Chloride Cotransporters: from Cloning to Structure and Function by John A. Payne 18. Regulation of Cation-Chloride Cotransporters by Gerardo Gamba, Nicole Garbarini and Eric Delpire Section IV Cation-chloride cotransporters in neural function and dysfunction 19. GABA, Glycine and Cation-Chloride Cotransporterts in Retinal Function and Development by Noga Vardi and ling-Li Zhang 20. Chloride-based Signal Amplification in Olfactory Sensory Neurons by Stephan Frings 21. Cochlear and Vestibular Function and Dysfunction by Daniel C. Marcus and Philine Wangemann 22. Presynaptic inhibition, pain and neurogenic inflammation by F. Javier Alvarez-Leefmans 23. Modulation of Chloride Homeostasis by Microglia by Yves De Koninck 24. Cation-Chloride Cotransporters as Pharmacological Targets in the Treatment of Epilepsy by Kristopher T. Kahle and Kevin Staley 25. The Role of Cation-Chloride Cotransporters in Brain Ischemia by Dandan Sun, Doug Kintner and Brooks B. Pond 26. Chloride Transport in Glioma Growth and Cell Invasion by Harald Sontheimer 27. The Sodium-Potassium-Chloride Cotransporter, Human Cytomegalovirus, and the Cell Cycle by John M. Russell Section V Cation-chloride cotransport in Choroid Plexus and blood brain barrier 28. Chloride Transporters as Water Pumps: Elements in a New Model of Epithelial Water Transport by Nanna MacAulay, Steffen Hamann, and Thomas Zeuthen 29. Choroid plexus and chloride transport by Peter D. Brown , Sarah L. Davies and Ian D. Millar 30. Ion and Water Transport Across the Blood-Brain Barrier by Martha E. O’Donnell

Reviews

""Overall, the authors and editors have done a marvelous job. I strongly recommend their book to those already in the Cl- field and those who need an introduction to it, because the topics are appealing for a specialized as well as a general audience. The editors have been very successful in getting an up-to-date review from many of the major players in the field and in covering the key topics (literature is cited until 2008). Although the pace of discoveries in the field is brisk, at present this book provides an excellent overview.""--The Physiologist

Overall, the authors and editors have done a marvelous job. I strongly recommend their book to those already in the Cl- field and those who need an introduction to it, because the topics are appealing for a specialized as well as a general audience. The editors have been very successful in getting an up-to-date review from many of the major players in the field and in covering the key topics (literature is cited until 2008). Although the pace of discoveries in the field is brisk, at present this book provides an excellent overview. --The Physiologist

Author Information

Research Interests Research in his laboratory focuses on the molecular and cellular physiology of carrier protein molecules that actively transport chloride ions (Cl-) across the plasma membrane of neurons and epithelial cells. Specifically, they study some members of the cation-coupled-chloride contransporter gene/protein family SLC12A: the Na+, K+, 2 Cl- cotransporters (NKCC1 and NKCC2) and the K+-Cl- cotransporters (KCC1, 2, 3 and 4). These carrier proteins play key roles in: intracellular Cl- homeostasis in neurons, GABA- and glycine-mediated synaptic signaling, neuronal development, sensory transduction including nociception, transepithelial salt transport, cell water volume control, and extracellular K+ scavenging. Not surprisingly, altered function of these proteins underlies several pathologies and hence they have become significant targets for therapeutic interventions and translational research. To study the function of these proteins we use state-of-the-art live-cell imaging microscopy and fluorescent probes for measuring and manipulating intracellular ions and water in dissociated neurons and epithelial cells. Some of these optical methods have been developed in their lab, and are used in conjunction with molecular methods, knockout models, and several microanatomical techniques. Their current research involves two projects: Mechanisms regulating intracellular chloride in primary afferent neurons and their impact on GABA-mediated presynaptic inhibition and sensory transduction. This project aims at understanding the molecular mechanisms that determine intracellular Cl- concentration in primary afferent neurons, their regulation, and the role they play in presynaptic inhibition, acute somatic pain, neurogenic inflammation and proprioception. Roles of cation-coupled-chloride contransporters of choroid plexus epithelial cells in the regulation of cerebrospinal fluid ion composition. The choroid plexus epithelial cells (CPECs) form the blood-cerebrospinal fluid (CSF) barrier. CPECs secrete CSF and regulate its electrolyte composition. Regulation of CSF ion levels is fundamental for maintaining normal brain function. The overarching goal of this project is to understand how NKCC1, KCCs and aquaporins control the ion composition of the cerebrospinal fluid. Current emphasis is on the molecular and cellular mechanisms used by CPECs to regulate and maintain the CSF K+ concentration, a fundamental problem of broad physiological significance. CSF composition has a major impact on the fluid microenvironment of neurons and glial cells, and vice versa. Extracellular K+ homeostasis is critical for normal brain function; small changes in extracellular K+ profoundly affect neuronal excitability and osmotic water balance of glial cells and neurons. Dr. Eric Delpire teaches at the Vanderbilt University, Nashville, USA

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