Overview

This is the fourth volume of the highly regarded ‘Physics of Cancer (Second Edition)’ series, written with the aim of making very important topics in the physics of cancer visible to the research community. This fourth volume deals with mechanobiology using biophysical methods. The first chapter deals with mechanosensing and mechanotransduction on vastly different length scales. The second chapter discusses biophysical techniques for mechanical phenotype characterization of cells and nuclei. The third provides an overview of the mechanical phenotype of the plasma membrane. The fourth chapter contains the latest insights into the mechanical assessment of cell spheroids, organoids and tumoroids. The basic approach of this text is to present the latest promising findings to the scientific community, addressing scientists at all career stages. Key Features Fourth volume of the author’s ‘Physics of Cancer (Second Edition)’ books, a highly regarded series Comprises chapters that have been designed as self-contained units Written by a widely respected expert in the physics of cancer field Covers state-of-the-art techniques that were developed by the author Includes research findings that have been presented in numerous peer-reviewed journal articles Contains extensive references at the end of each chapter to enhance further study

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9780750340014

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Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumormicroenvironment mechanics. She has published over 150 referred journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.

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