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Author:   Humphrey Moynihan (Department of Chemistry, University College Cork.) ,  Abina Crean (School of Pharmacy, University College Cork.)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 18.90cm , Height: 1.40cm , Length: 24.50cm
Weight:   0.698kg
ISBN:  

9780199232840

ISBN 10:   0199232849
Pages:   320
Publication Date:   23 July 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

1. Pharmaceuticals and medicines 1.1: Introduction to the essential properties of pharmaceuticals 1.1.1: Some key concepts 1.2: Classes of pharmaceutical compounds 1.2.1: Active pharmaceutical ingredients 1.2.2: Excipients 1.3: Drug delivery: getting the active pharmaceutical ingredient to the site of action 1.3.1: Routes of administration 1.3.2: Pharmaceutical dosage forms 1.3.3: Factors influencing dosage form choice 1.4: Summary 2. Pharmaceutical solutions 2.2: Definitions and expressions of solubility 2.1.1: Measurement of solubility and solubility curves 2.2: Solvent structure 2.2.1: Hydrogen bonding and the structure of water 2.2.2: Lipid-based media 2.3: Dissolution and solvation 2.4: Factors affecting solubility 2.4.1: Molecular weight 2.4.2: Hydrogen bonding 2.4.3: Hydrophobic and hydrophilic groups 2.5: Acidity and basicity 2.5.1: pKa and pKb 2.5.2: Acidity and environment 2.6: Salt selection and formation 2.7: Hydrolytic degradation 2.8: Summary 3. Pharmaceutical equilibria 3.1: Essential concepts in thermodynamics 3.1.1: Internal energy, enthalpy and the first law of thermodynamics 3.1.2: Entropy and the second and third laws of thermodynamics 3.1.3: Free energy, chemical potential and equilibrium 3.1.4: Activities of ions in solution 3.2: Phase equilibria 3.2.1: One-component systems and the phase rule 3.2.2: Two-component systems 3.2.3: Osmotic pressure 3.3: Drug delivery: Phase transitions 3.3.1: Diffusion (movement within a phase) 3.3.2: Dissolution (solid -liquid transition) 3.3.3: Partitioning (liquid- liquid transition) 3.3.4: Gas absorption (Gas-liquid phase transition) 3.3.5: Phase transitions during drug delivery 3.4: Summary 4. The pharmaceutical solid phase 4.1: Crystalline and amorphous solids 4.2: The essentials of pharmaceutical crystal structure 4.2.1: Unit cells, crystal systems and lattices 4.2.2: Space groups and space group notation 4.2.3: Crystal planes and faces 4.3: Crystal polymorphism of pharmaceuticals 4.3.1: Relative stabilities of polymorphs 4.3.2: Solvates and hydrates 4.4: Methods of characterising pharmaceutical solids 4.4.1: X-ray diffraction methods 4.4.2: Thermal methods 4.4.3: Other methods of analysis 4.5: Pharmaceutical crystallization 4.5.1: Supersaturation 4.5.2: Nucleation, growth and crystal morphology 4.5.3: Ripening and the rule of stages 4.6: Solid state properties of powder particles 4.6.1: Particle shape 4.6.2: Particle size 4.6.3: Particle surface properties 4.6.4: Gas adsorption 4.6.5: Moisture adsorption 4.6.6: Powder mechanical strength 5. Two phase solid - liquid disperse systems 5.1: Introduction to pharmaceutical disperse systems 5.2: Molecular, colloidal and coarse dispersions 5.3: The physical stability of disperse systems 5.4: Properties of disperse systems 5.4.1: Kinetic properties 5.4.2: Rheology and viscosity 5.4.3: Electrical properties 5.4.4: Interfacial properties 5.4.5: Optical properties 5.5: Suspensions 5.5.1: Nanosuspensions 5.5.2: Coarse suspensions 5.6: Emulsions 5.6.1: Macroemulsions 5.6.2: Multiple emulsions 5.6.3: Microemulsions 5.7: Vesicular systems 5.7.1: Micellar systems 5.7.2: Solubilised systems 5.7.3: Liposomes 5.8: Aerosols 5.9: Foams 5.10: Summary 6. Biological interfaces 6.1: Passive, active and other modes of transport 6.2: Cell membranes 6.3: Partition and partition co-efficients 6.4: Measurement and calculation of partition co-efficients 6.5: Diffusion, diffusion co-efficients and ionisation 6.6: The gastrointestinal barrier 6.7: The blood-brain barrier 6.8: The skin 6.9: Summary 7. Physicochemical aspects of Pharmacokinetics and Pharmacodynamics 7.1: Bioavailability 7.2: Distribution 7.3: Drug target interaction 7.4: Metabolism 7.5: Excretion 7.6: Summary

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Author Information

Having originally received his BSc and PhD degrees from University College Cork, Humphrey Moynihan returned in 2002, where he is now involved in the teaching of Organic and Pharmaceutical/Medicinal Chemistry. His research interest is the study and control of crystallisation of organic compounds. He is also involved in collaborative research in areas such as Analytical Chemistry. Abina Crean joined the Cork School of Pharmacy in September 2004 as a Lecturer in Pharmaceutics after working in formulation and process development for Élan Pharmaceutical Technologies and Servier (Ireland) Industries. Her main research interests are in the areas of solid dose drug delivery systems and pharmaceutical solid-state properties.

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