Overview

Physicochemical Approaches to the Characterization of Pharmaceutical Systems provides consistent data analysis on the basic physics and chemistry involved in pharmaceutical systems that are carried out using various theoretical models. The book explores states of matter and thermodynamics, how to estimate chemical properties, solubility and distribution phenomena, kinetic processes and drug delivery, and thermodynamics versus the shape of molecules. It supplies several guidelines for achieving better estimations of properties associated with complex molecular geometries, such as important drug, polymer and biopolymer characteristics. Researchers will find it to be a crucial resource for studies in pharmaceutical science and chemical engineering.

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Nicola De Zordi (1983) is going to take his Ph.D. within the School of Chemical and Pharmaceutical Sciences and Technologies at the University of Trieste. His expertise is ranging from pharmaceutical chemistry and chemical thermodynamics principles (involved particularly in the preparation of oral solid dosage forms) to their industrial applications. He is the author/coauthor of more than ten publications, published in international journals and conference proceedings, and acting as a referee for the scientific community. Mario Grassi has a graduate degree in Chemical Engineering from Trieste University, and a Ph.D. in Chemical Engineering from Padova University (Italy). He has received multiple grants to study topics such as diffusion processes and drug activation by means of mechano-chemical activation, drug diffusion in polymeric matrices and release processes, and viscoelastic and rheological properties of polymeric systems. From 2002-2004 he worked for EURAND as co-ordinator of the Trieste site research activities. In 2005 he became associate professor (Faculty of Engineering of the Trieste University). Since 2011 he has been member of the editorial board of the international journals Chemical and Biochemical Engineering Quarterly (CABEQ) and World Journal of Pharmacology. Dr. Grassi has authored or co-authored more than 100 papers in international journals and more than 150 congress communications. He is also a co-author of Understanding drug release and absorption mechanisms: a physical and mathematical approach (CRC Press, 2007). Since 2012 he has been vice-president of the Doctorate School in Chemistry, University of Trieste, and in May 2013 he became chairman of the board of professors, Master degree in Chemical and Materials Engineering, University of Trieste. Gabriele Grassi has a degree in Medicine from the University of Trieste, and a degree of Magister Philosophiae and Ph.D. from I.S.A.S. From 1995-1997 Dr. Grassi was a Visiting Fellow at the National Institutes of Health in the laboratory of Dr J.C. Marini (Human Genetic Branch, National Institute of Child Heritable Disorders). From 1997-2003 Dr. Grassi was a scientist assistant in the Department of Molecular Pathology of the University of Tuebingen, Germany, directed by Prof. Dr. R. Kandolf and in 2003 he was a guest editor of the theme issue Nucleic Acid Molecules with Therapeutical Properties for the journal Current Pharmaceutical Biotechnology. Between March 2003 and September 2007 Dr. Grassi served as a consultant professor in the Department of Internal Medicine of the University Hospital of Cattinara (Italy). October 2007- Associate professor in the Department of Life Sciences of the University of Trieste; November 2009-: Chairman of the board of professors, Master degree in Medical Biotechnology, University of Trieste; December 2011- guest scientist in the Department of Molecular Pathology of the University of Tuebingen, Germany; November 2012-: Chairman of the board of professors, Master degree in Functional Genomic, University of Trieste; June 2013: Guest editor of the theme issue: Improving drug efficacy and specificity by innovative drug delivery approaches for the journal Current Medicinal Chemistry. Ireneo Kikic (1942) is a Full Professor of Chemical Engineering at the University of Trieste since 1980, and of Chemical Engineering Thermodynamics since 1993. He retired in 2010, but continues to teach and research, either supervising undergraduate and graduate students, or collaborating with several international institutions, such as the European Universities of Graz, Marseille, Delft, and Athens. He was the Director of the Institute of Industrial and Applied Chemistry (1982-1988) and Head of the Department of Chemical Engineering (DICAMP), still in Trieste (1997-2003). He worked also at the Ecole des Mines of Paris (1974, 1980), at the Technical University of Denmark (1978, 1986) and, as a Visiting Professor, at the University of Paris XIII (2003). He gave seminars at different Universities in Italy and Europe (Lyngby, Dortmund, Hamburg, Marseille, Zurich, Porto) and attended a number of international and national Conferences on Applied Thermodynamics and Supercritical Fluid Technology, part of which attended as an invited speaker. He was member of the Scientific Committee for the 1st, 3rd and 4th International Conferences on Supercritical Fluids and, in 1992, the Chairman of the 6th International Conference on Fluid Properties and Phase Equilibria for Chemical Process Design. Jointly to Proff. Perrut and Brunner, he was also the Chairman of the 6th International Symposium on Supercritical Fluids in Versailles (2003). In Trieste (2004), he was one of the organizers of the 9th Meeting on Supercritical Fluids, within the 7th Italian Conference on Supercritical Fluids. Among the editorial achievements, there emerges his participation in the Editorial Boards of Fluid Phase Equilibria and, currently, the Journal of Supercritical Fluids. He is a member of the Working Party High Pressure Technology of the European Federation of Chemical Engineering, and has been a former President of the International Society for the Advancement of Supercritical Fluids (ISASF, 1999-2007), in which he remained as a Vice President. His research activity can be easily documented by more than three hundreds papers published in international journals, book chapters, and proceedings of national and international conferences. Prof. M. Moneghini is an Associate Professor and pharmaceutical scientist at the Faculty of Pharmacy of the University of Trieste. From the beginning of 90's years, at the time of her first permanent position, she has been teaching numerous courses for the degree in Pharmacy and in Pharmaceutical Chemistry and Technology. Among the main research topics she is currently working on, the innovative preparation and characterization of modified drug release oral solid dosage forms (tablets, granules, microspheres and extrudes) play a special role. The idea is to benefit in fact from novel and advanced formulation methods, such as microwave irradiation and supercritical fluid techniques, creating a cross-disciplinary environment of pharmaceutical interest. She is also the first author and co-author of more than about one hundred publications, sixty of being published in international journals, and the others appeared both in international and national conference proceedings. S.A. Mezzasalma is a contract professor and researcher at the University of Trieste and, in particular, a theoretical chemical physicist of soft condensed matter. His main research activity covered a number of topics in macromolecular, colloid and interface sciences, producing several tens of single-authored publications. Author of a recent book, Macromolecules in Solution and Brownian Relativity , published within the Interface Science and Technology Series of Academic Press & Elsevier (2008). He lately started to work on several issues in nanoscience and supramolecular chemistry, and collaborate within the EC Advanced Grant Carbonanobridge , at the cutting edge between chemical and biological physics.

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